| SP | Koufax, S.Koufax, Sandy $ >> | 30 | 1965 | L | 97 | 34 | 34 | 10 | 19 | 4.85 | .315 | 1.35 | 9.1 | 3.1 | 7.8 | 209.2 | 212 | 117 | 113 | 28 | 71 | 180 | 6 | 0 | 0 | 0 | 14 | 6 | 4 | 4.12 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 33 | 33 | 8 | 17 | 5.23 | .332 | 1.46 | 10.5 | 2.6 | 5.2 | 201.1 | 235 | 129 | 117 | 21 | 59 | 116 | 5 | 0 | 0 | 1 | 12 | 6 | 1 | 4.17 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 73 | 32 | 32 | 8 | 14 | 4.73 | .322 | 1.41 | 9.8 | 2.9 | 4.7 | 211.1 | 230 | 121 | 111 | 29 | 68 | 110 | 2 | 0 | 0 | 0 | 16 | 3 | 2 | 4.75 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 32 | 31 | 8 | 17 | 4.97 | .321 | 1.40 | 9.7 | 2.9 | 4.6 | 199.0 | 215 | 116 | 110 | 27 | 64 | 101 | 6 | 1 | 0 | 0 | 14 | 3 | 6 | 4.76 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 99 | 0 | 6 | 6 | 4.17 | .283 | 1.15 | 6.7 | 3.7 | 7.4 | 131.2 | 98 | 61 | 61 | 17 | 54 | 107 | 0 | 8 | 2 | 0 | 0 | 4 | 0 | 4.38 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 83 | 0 | 6 | 3 | 3.75 | .311 | 1.32 | 8.0 | 3.9 | 7.4 | 98.1 | 87 | 42 | 41 | 11 | 43 | 81 | 0 | 7 | 4 | 0 | 0 | 3 | 0 | 4.21 |
| RP | Clippard, T.Clippard, Tyler # >> | 26 | 2011 | R | 79 | 67 | 0 | 2 | 5 | 4.63 | .323 | 1.41 | 8.7 | 4.1 | 9.0 | 81.2 | 78 | 46 | 42 | 11 | 37 | 81 | 0 | 9 | 2 | 0 | 0 | 2 | 1 | 4.21 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 54 | 0 | 5 | 2 | 3.21 | .295 | 1.20 | 5.7 | 5.1 | 10.2 | 70.0 | 44 | 28 | 25 | 8 | 40 | 79 | 0 | 2 | 4 | 0 | 0 | 4 | 1 | 4.11 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 45 | 0 | 2 | 3 | 4.35 | .389 | 1.87 | 9.7 | 7.3 | 10.1 | 49.2 | 53 | 26 | 24 | 3 | 40 | 55 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 4.12 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 9 | 0 | 1 | 0 | 0.00 | .220 | 0.84 | 2.7 | 5.4 | 12.6 | 10.2 | 3 | 0 | 0 | 0 | 6 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |