| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 35 | 35 | 14 | 12 | 3.99 | .278 | 1.14 | 7.5 | 2.8 | 9.3 | 228.0 | 189 | 103 | 101 | 30 | 70 | 236 | 0 | 0 | 0 | 0 | 21 | 4 | 0 | 3.61 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 32 | 32 | 15 | 8 | 3.25 | .278 | 1.14 | 7.6 | 2.7 | 5.0 | 227.1 | 191 | 89 | 82 | 16 | 69 | 127 | 3 | 0 | 0 | 0 | 22 | 3 | 5 | 3.75 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 27 | 22 | 10 | 6 | 3.44 | .285 | 1.18 | 7.3 | 3.3 | 5.2 | 196.0 | 160 | 88 | 75 | 18 | 71 | 114 | 1 | 0 | 0 | 0 | 11 | 3 | 7 | 4.16 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 32 | 21 | 12 | 8 | 3.57 | .288 | 1.19 | 8.4 | 2.4 | 3.9 | 176.2 | 164 | 76 | 70 | 13 | 47 | 77 | 7 | 0 | 0 | 3 | 12 | 3 | 3 | 3.94 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 71 | 0 | 3 | 2 | 1.63 | .184 | 0.68 | 5.1 | 1.1 | 5.6 | 60.2 | 34 | 12 | 11 | 4 | 7 | 37 | 0 | 10 | 2 | 0 | 0 | 0 | 0 | 2.98 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 42 | 0 | 2 | 1 | 4.33 | .283 | 1.15 | 5.7 | 4.7 | 8.3 | 27.0 | 17 | 13 | 13 | 3 | 14 | 25 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.26 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 64 | 0 | 6 | 9 | 3.75 | .321 | 1.40 | 6.2 | 6.5 | 9.8 | 60.0 | 41 | 28 | 25 | 10 | 43 | 65 | 0 | 35 | 7 | 0 | 0 | 1 | 6 | 5.20 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 58 | 0 | 1 | 2 | 4.10 | .375 | 1.80 | 7.9 | 8.6 | 11.4 | 41.2 | 36 | 21 | 19 | 4 | 39 | 52 | 0 | 4 | 2 | 0 | 0 | 0 | 2 | 4.59 |
| RP | McGraw, T.McGraw, Tug # >> | 36 | 1980 | L | 51 | 31 | 0 | 3 | 1 | 5.54 | .361 | 1.69 | 9.7 | 5.5 | 5.2 | 26.0 | 28 | 18 | 16 | 2 | 16 | 15 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 4.69 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 17 | 0 | 1 | 1 | 5.54 | .316 | 1.38 | 8.3 | 4.2 | 6.9 | 13.0 | 12 | 8 | 8 | 1 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.85 |
| SP | Waddell, R.Waddell, Rube † >> | 29 | 1905 | L | 67 | 28 | 21 | 11 | 6 | 4.44 | .317 | 1.35 | 8.7 | 3.5 | 5.3 | 156.0 | 150 | 79 | 77 | 21 | 61 | 92 | 3 | 0 | 0 | 1 | 10 | 6 | 10 | 4.86 |