| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 8 | 8 | 3 | 3 | 3.96 | .276 | 1.15 | 6.9 | 3.5 | 10.2 | 52.1 | 40 | 23 | 23 | 7 | 20 | 59 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 3.63 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 7 | 7 | 5 | 1 | 1.32 | .248 | 0.97 | 6.0 | 2.8 | 3.8 | 54.2 | 36 | 8 | 8 | 1 | 17 | 23 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 3.39 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 7 | 7 | 4 | 3 | 3.92 | .299 | 1.26 | 7.7 | 3.8 | 3.8 | 43.2 | 37 | 20 | 19 | 4 | 18 | 18 | 2 | 0 | 0 | 1 | 4 | 1 | 1 | 4.70 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 7 | 7 | 4 | 1 | 3.65 | .318 | 1.34 | 8.4 | 3.7 | 5.9 | 49.1 | 46 | 20 | 20 | 5 | 20 | 32 | 1 | 0 | 0 | 0 | 3 | 3 | 5 | 4.43 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 16 | 0 | 0 | 0 | 3.14 | .368 | 1.74 | 9.0 | 7.1 | 11.6 | 14.1 | 14 | 6 | 5 | 1 | 11 | 18 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 3.71 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 14 | 0 | 1 | 2 | 3.65 | .213 | 0.81 | 5.3 | 2.3 | 5.3 | 12.1 | 7 | 5 | 5 | 2 | 3 | 7 | 0 | 6 | 2 | 0 | 0 | 0 | 0 | 4.75 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 9 | 0 | 0 | 0 | 11.81 | .429 | 2.06 | 9.0 | 10.8 | 9.0 | 5.1 | 5 | 7 | 7 | 2 | 6 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 10.40 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 5 | 0 | 0 | 0 | 6.00 | .182 | 0.67 | 3.0 | 3.0 | 9.0 | 3.0 | 1 | 2 | 2 | 0 | 1 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.00 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 4 | 0 | 1 | 0 | 9.00 | .455 | 2.50 | 18.0 | 4.5 | 4.5 | 2.0 | 4 | 2 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 4 | 0 | 0 | 0 | 2.57 | .232 | 0.90 | 6.4 | 1.7 | 3.4 | 21.0 | 15 | 7 | 6 | 1 | 4 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 3.43 |