| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 24 | 24 | 8 | 4 | 3.16 | .279 | 1.15 | 7.4 | 2.9 | 8.7 | 151.0 | 124 | 60 | 53 | 15 | 49 | 146 | 0 | 0 | 0 | 0 | 19 | 2 | 0 | 3.37 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 80 | 23 | 23 | 8 | 10 | 5.59 | .323 | 1.42 | 9.1 | 3.7 | 7.8 | 116.0 | 117 | 73 | 72 | 19 | 48 | 100 | 0 | 0 | 0 | 0 | 10 | 1 | 10 | 4.67 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 23 | 23 | 10 | 11 | 4.75 | .303 | 1.27 | 9.1 | 2.4 | 4.0 | 151.2 | 153 | 85 | 80 | 16 | 40 | 67 | 5 | 0 | 0 | 0 | 9 | 5 | 6 | 4.38 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 22 | 22 | 10 | 8 | 3.70 | .289 | 1.19 | 8.2 | 2.6 | 4.7 | 153.1 | 139 | 65 | 63 | 16 | 44 | 80 | 10 | 0 | 0 | 3 | 12 | 4 | 0 | 4.25 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 67 | 0 | 7 | 1 | 3.47 | .312 | 1.34 | 6.2 | 5.9 | 8.7 | 83.0 | 57 | 32 | 32 | 7 | 54 | 80 | 0 | 3 | 2 | 0 | 0 | 2 | 9 | 4.19 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 58 | 0 | 5 | 3 | 3.18 | .281 | 1.16 | 6.2 | 4.4 | 9.0 | 70.2 | 48 | 25 | 25 | 6 | 34 | 70 | 0 | 8 | 1 | 0 | 0 | 1 | 9 | 3.61 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 42 | 0 | 1 | 3 | 3.22 | .311 | 1.35 | 8.5 | 3.8 | 8.5 | 50.1 | 47 | 21 | 18 | 1 | 21 | 47 | 0 | 7 | 2 | 0 | 0 | 0 | 6 | 2.64 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 42 | 0 | 5 | 0 | 2.10 | .260 | 1.01 | 6.4 | 2.8 | 7.8 | 51.1 | 36 | 12 | 12 | 3 | 16 | 44 | 0 | 2 | 2 | 0 | 0 | 2 | 3 | 3.10 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 31 | 0 | 2 | 1 | 3.39 | .300 | 1.27 | 7.0 | 4.5 | 6.2 | 58.1 | 45 | 23 | 22 | 8 | 29 | 40 | 0 | 5 | 0 | 0 | 0 | 1 | 1 | 4.97 |