| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 32 | 32 | 15 | 10 | 4.04 | .282 | 1.15 | 7.3 | 3.1 | 9.0 | 222.2 | 179 | 103 | 100 | 26 | 77 | 223 | 4 | 0 | 0 | 1 | 18 | 7 | 5 | 3.65 |
| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 34 | 34 | 14 | 13 | 3.76 | .292 | 1.22 | 7.9 | 3.1 | 8.2 | 263.0 | 230 | 115 | 110 | 33 | 92 | 240 | 15 | 0 | 0 | 4 | 20 | 4 | 6 | 3.90 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 32 | 32 | 9 | 15 | 4.98 | .326 | 1.42 | 9.2 | 3.7 | 4.2 | 240.1 | 244 | 141 | 133 | 29 | 98 | 112 | 9 | 0 | 0 | 3 | 11 | 7 | 2 | 4.95 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 32 | 32 | 13 | 11 | 4.29 | .320 | 1.39 | 8.8 | 3.7 | 5.0 | 218.1 | 214 | 110 | 104 | 21 | 90 | 122 | 4 | 0 | 0 | 3 | 18 | 4 | 2 | 4.43 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 30 | 30 | 10 | 14 | 4.70 | .302 | 1.27 | 9.2 | 2.2 | 4.6 | 227.2 | 232 | 124 | 119 | 29 | 56 | 115 | 13 | 0 | 0 | 3 | 11 | 7 | 5 | 4.48 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 85 | 0 | 11 | 9 | 4.48 | .304 | 1.31 | 8.4 | 3.4 | 7.9 | 96.1 | 90 | 52 | 48 | 17 | 36 | 84 | 0 | 13 | 6 | 0 | 0 | 0 | 6 | 4.68 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 54 | 0 | 1 | 3 | 3.01 | .287 | 1.18 | 6.2 | 4.5 | 7.2 | 74.2 | 51 | 27 | 25 | 4 | 37 | 59 | 0 | 6 | 0 | 0 | 0 | 2 | 0 | 3.69 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 24 | 0 | 1 | 2 | 4.72 | .322 | 1.43 | 9.8 | 3.2 | 5.8 | 34.1 | 37 | 24 | 18 | 9 | 12 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 6.21 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 11 | 0 | 2 | 1 | 3.38 | .298 | 1.28 | 8.3 | 3.5 | 8.3 | 13.1 | 12 | 7 | 5 | 3 | 5 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.31 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 57 | 18 | 0 | 0 | 0 | 5.95 | .337 | 1.47 | 9.5 | 4.3 | 9.9 | 19.2 | 20 | 13 | 13 | 1 | 9 | 21 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.05 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 5 | 2 | 2 | 2 | 6.38 | .321 | 1.36 | 11.0 | 1.5 | 5.5 | 18.1 | 22 | 15 | 13 | 5 | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.06 |