| SP | Titcomb, C.Titcomb, Cannonball >> | 22 | 1888 | L | 99 | 18 | 18 | 3 | 10 | 4.44 | .288 | 1.21 | 8.4 | 2.5 | 5.9 | 121.2 | 113 | 62 | 60 | 7 | 34 | 79 | 5 | 0 | 0 | 0 | 7 | 1 | 3 | 3.31 |
| SP | Bradley, G.Bradley, George >> | 22 | 1884 | R | 72 | 16 | 16 | 3 | 10 | 5.50 | .323 | 1.42 | 10.8 | 2.1 | 4.5 | 109.2 | 131 | 67 | 67 | 7 | 25 | 54 | 4 | 0 | 0 | 0 | 7 | 1 | 0 | 3.56 |
| SP | Bernhard, B.Bernhard, Bill >> | 22 | 1904 | R | 63 | 12 | 12 | 6 | 4 | 4.02 | .314 | 1.35 | 9.3 | 2.9 | 3.9 | 87.1 | 90 | 42 | 39 | 7 | 28 | 38 | 1 | 0 | 0 | 0 | 6 | 2 | 2 | 4.21 |
| SU | Magnante, M.Magnante, Mike >> | 22 | 1997 | L | 90 | 27 | 0 | 1 | 0 | 2.16 | .270 | 1.05 | 6.5 | 3.0 | 6.0 | 33.1 | 24 | 11 | 8 | 2 | 11 | 22 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 3.64 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 22 | 2009 | R | 90 | 29 | 0 | 0 | 0 | 0.87 | .268 | 1.06 | 6.4 | 3.2 | 5.8 | 31.0 | 22 | 3 | 3 | 0 | 11 | 20 | 0 | 11 | 1 | 0 | 0 | 1 | 0 | 2.87 |
| RP | Russell, J.Russell, Jeff >> | 22 | 1993 | R | 83 | 38 | 0 | 2 | 2 | 4.50 | .345 | 1.58 | 10.3 | 3.9 | 5.4 | 48.0 | 55 | 29 | 24 | 2 | 21 | 29 | 0 | 0 | 2 | 0 | 0 | 0 | 4 | 3.65 |
| RP | Guerra, D.Guerra, Deolis >> | 22 | 2016 | R | 67 | 40 | 0 | 3 | 3 | 4.43 | .354 | 1.59 | 11.4 | 3.2 | 5.1 | 42.2 | 53 | 23 | 21 | 1 | 15 | 24 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 3.38 |
| RP | Casilla, S.Casilla, Santiago >> | 22 | 2017 | R | 53 | 25 | 0 | 1 | 2 | 4.76 | .336 | 1.48 | 8.4 | 5.1 | 7.1 | 28.1 | 26 | 15 | 15 | 1 | 16 | 22 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 3.71 |