| SP | Titcomb, C.Titcomb, Cannonball >> | 22 | 1888 | L | 99 | 13 | 13 | 2 | 7 | 4.71 | .306 | 1.31 | 8.4 | 3.4 | 5.5 | 84.0 | 78 | 46 | 44 | 7 | 32 | 51 | 3 | 0 | 0 | 0 | 5 | 1 | 3 | 4.05 |
| SP | Bradley, G.Bradley, George >> | 22 | 1884 | R | 72 | 12 | 12 | 2 | 7 | 4.94 | .305 | 1.31 | 10.1 | 1.8 | 4.4 | 85.2 | 95 | 47 | 47 | 5 | 17 | 42 | 3 | 0 | 0 | 0 | 6 | 1 | 0 | 3.41 |
| SP | Bernhard, B.Bernhard, Bill >> | 22 | 1904 | R | 63 | 9 | 9 | 4 | 3 | 3.99 | .319 | 1.38 | 9.3 | 3.2 | 4.2 | 65.1 | 67 | 32 | 29 | 5 | 23 | 30 | 1 | 0 | 0 | 0 | 4 | 2 | 1 | 4.23 |
| SU | Magnante, M.Magnante, Mike >> | 22 | 1997 | L | 90 | 17 | 0 | 1 | 0 | 2.45 | .275 | 1.05 | 8.2 | 1.2 | 5.7 | 22.0 | 20 | 8 | 6 | 2 | 3 | 14 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.59 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 22 | 2009 | R | 90 | 20 | 0 | 0 | 0 | 0.41 | .258 | 1.00 | 6.1 | 2.9 | 7.4 | 22.0 | 15 | 1 | 1 | 0 | 7 | 18 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 2.45 |
| RP | Russell, J.Russell, Jeff >> | 22 | 1993 | R | 83 | 28 | 0 | 2 | 1 | 4.14 | .315 | 1.38 | 10.2 | 2.2 | 6.1 | 37.0 | 42 | 21 | 17 | 2 | 9 | 25 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 3.08 |
| RP | Guerra, D.Guerra, Deolis >> | 22 | 2016 | R | 67 | 31 | 0 | 3 | 3 | 3.82 | .344 | 1.52 | 9.8 | 3.8 | 4.6 | 33.0 | 36 | 16 | 14 | 1 | 14 | 17 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 3.82 |
| RP | Casilla, S.Casilla, Santiago >> | 22 | 2017 | R | 53 | 20 | 0 | 1 | 1 | 5.48 | .354 | 1.59 | 8.6 | 6.0 | 6.0 | 21.1 | 20 | 13 | 13 | 1 | 14 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.43 |