| SP | Verlander, J.Verlander, Justin † >> | 27 | 2010 | R | 89 | 36 | 36 | 15 | 11 | 3.58 | .292 | 1.21 | 7.7 | 3.2 | 6.0 | 234.0 | 200 | 101 | 93 | 22 | 84 | 157 | 2 | 0 | 0 | 0 | 23 | 5 | 11 | 4.02 |
| SP | Tiant, L.Tiant, Luis # >> | 34 | 1974 | R | 83 | 35 | 35 | 12 | 12 | 4.10 | .317 | 1.37 | 9.5 | 2.8 | 5.6 | 215.0 | 227 | 100 | 98 | 21 | 67 | 133 | 8 | 0 | 0 | 3 | 18 | 6 | 3 | 4.05 |
| SP | Douglas, P.Douglas, Phil >> | 27 | 1917 | R | 85 | 33 | 33 | 8 | 15 | 4.92 | .328 | 1.43 | 10.3 | 2.6 | 5.0 | 179.1 | 205 | 106 | 98 | 18 | 52 | 100 | 1 | 0 | 0 | 1 | 13 | 6 | 2 | 4.16 |
| SP | Ruffing, R.Ruffing, Red >> | 27 | 1932 | R | 76 | 34 | 33 | 10 | 14 | 5.65 | .364 | 1.69 | 9.3 | 6.0 | 5.7 | 170.1 | 175 | 113 | 107 | 15 | 113 | 108 | 0 | 0 | 0 | 0 | 13 | 4 | 8 | 4.94 |
| CL | Rivera, M.Rivera, Mariano † >> | 42 | 2011 | R | 97 | 62 | 0 | 2 | 2 | 1.62 | .234 | 0.89 | 6.3 | 1.8 | 5.7 | 66.2 | 46 | 15 | 12 | 4 | 13 | 42 | 0 | 42 | 4 | 0 | 0 | 2 | 1 | 3.20 |
| RP | Henry, D.Henry, Dwayne >> | 30 | 1992 | R | 80 | 76 | 0 | 7 | 4 | 3.95 | .346 | 1.56 | 8.5 | 5.7 | 6.7 | 70.2 | 66 | 34 | 31 | 2 | 44 | 52 | 0 | 0 | 4 | 0 | 0 | 2 | 12 | 3.86 |
| RP | Lavelle, G.Lavelle, Gary >> | 28 | 1977 | L | 67 | 87 | 0 | 3 | 0 | 4.52 | .323 | 1.39 | 9.5 | 3.1 | 3.6 | 67.2 | 71 | 34 | 34 | 6 | 23 | 27 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.52 |
| RP | Alexander, S.Alexander, Scott >> | 27 | 2017 | L | 56 | 58 | 0 | 3 | 4 | 7.64 | .369 | 1.73 | 11.6 | 4.1 | 8.0 | 35.1 | 45 | 31 | 30 | 4 | 16 | 31 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.17 |
| RP | Tavarez, J.Tavarez, Julian >> | 30 | 2003 | R | 52 | 70 | 0 | 5 | 1 | 6.47 | .351 | 1.60 | 11.3 | 3.4 | 3.9 | 48.2 | 60 | 38 | 35 | 5 | 18 | 21 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 4.67 |
| RP | Sauerbeck, S.Sauerbeck, Scott >> | 28 | 1999 | L | 57 | 34 | 0 | 2 | 1 | 3.00 | .262 | 1.03 | 5.7 | 3.6 | 5.7 | 30.0 | 19 | 12 | 10 | 3 | 12 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.33 |
| RP | Alvarez, J.Alvarez, Jose >> | 33 | 1989 | R | 51 | 45 | 0 | 4 | 0 | 4.97 | .349 | 1.61 | 9.4 | 5.3 | 7.5 | 41.2 | 43 | 23 | 23 | 3 | 24 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.05 |