| SP | Wainwright, A.Wainwright, Adam >> | 29 | 2010 | R | 97 | 25 | 25 | 6 | 13 | 3.93 | .328 | 1.43 | 9.5 | 3.4 | 6.4 | 178.2 | 188 | 81 | 78 | 4 | 68 | 126 | 1 | 0 | 0 | 0 | 14 | 6 | 1 | 3.12 |
| SP | Langston, M.Langston, Mark # >> | 33 | 1993 | L | 81 | 25 | 25 | 10 | 8 | 4.14 | .313 | 1.34 | 8.6 | 3.4 | 5.7 | 189.0 | 181 | 89 | 87 | 17 | 72 | 120 | 3 | 0 | 0 | 0 | 13 | 5 | 4 | 4.12 |
| SP | Winter, G.Winter, George >> | 27 | 1905 | R | 69 | 24 | 24 | 8 | 13 | 4.83 | .325 | 1.41 | 9.8 | 2.9 | 5.3 | 173.1 | 189 | 96 | 93 | 16 | 56 | 101 | 4 | 0 | 0 | 1 | 8 | 5 | 4 | 4.09 |
| SP | Quintana, J.Quintana, Jose >> | 35 | 2024 | L | 65 | 24 | 24 | 10 | 5 | 4.86 | .318 | 1.37 | 8.5 | 3.8 | 6.2 | 137.0 | 130 | 74 | 74 | 14 | 58 | 95 | 0 | 0 | 0 | 0 | 8 | 4 | 1 | 4.30 |
| SP | Porcello, R.Porcello, Rick >> | 24 | 2013 | R | 46 | 24 | 24 | 8 | 6 | 6.23 | .352 | 1.55 | 11.4 | 2.7 | 5.8 | 128.2 | 162 | 92 | 89 | 16 | 38 | 83 | 0 | 0 | 0 | 0 | 8 | 10 | 5 | 4.45 |
| RP | Gregerson, L.Gregerson, Luke # >> | 32 | 2016 | R | 96 | 69 | 0 | 8 | 4 | 5.68 | .336 | 1.49 | 9.0 | 4.5 | 8.5 | 82.1 | 82 | 54 | 52 | 8 | 41 | 77 | 0 | 4 | 3 | 0 | 0 | 2 | 8 | 3.96 |
| RP | Cano, Y.Cano, Yennier † >> | 29 | 2023 | R | 82 | 59 | 0 | 7 | 1 | 3.20 | .269 | 1.08 | 7.6 | 2.2 | 6.0 | 78.2 | 66 | 29 | 28 | 8 | 19 | 52 | 0 | 10 | 5 | 0 | 0 | 2 | 1 | 3.81 |
| RP | Brennan, B.Brennan, Brandon >> | 27 | 2019 | R | 67 | 42 | 0 | 3 | 1 | 2.78 | .284 | 1.17 | 6.4 | 4.2 | 8.8 | 45.1 | 32 | 15 | 14 | 4 | 21 | 44 | 0 | 9 | 1 | 0 | 0 | 1 | 6 | 3.67 |
| RP | Valverde, J.Valverde, Jose >> | 33 | 2012 | R | 50 | 26 | 0 | 2 | 3 | 4.60 | .353 | 1.64 | 9.0 | 5.9 | 5.3 | 29.1 | 29 | 16 | 15 | 4 | 19 | 17 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 5.59 |
| RP | Shouse, B.Shouse, Brian >> | 35 | 2003 | L | 39 | 29 | 0 | 0 | 0 | 2.97 | .329 | 1.44 | 9.8 | 3.3 | 4.4 | 33.1 | 36 | 13 | 11 | 3 | 12 | 16 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.39 |