| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 92 | 17 | 17 | 7 | 6 | 3.40 | .274 | 1.12 | 7.6 | 2.6 | 6.3 | 108.2 | 91 | 42 | 41 | 15 | 31 | 75 | 2 | 0 | 0 | 1 | 0 | 1 | 2 | 4.31 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 79 | 6 | 5 | 0 | 2 | 10.24 | .442 | 2.38 | 14.2 | 7.6 | 9.5 | 19.1 | 30 | 23 | 22 | 4 | 16 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.16 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 66 | 14 | 14 | 3 | 8 | 5.08 | .293 | 1.23 | 8.0 | 3.1 | 3.8 | 78.0 | 69 | 46 | 44 | 15 | 27 | 33 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.73 |
| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 89 | 14 | 13 | 3 | 5 | 4.82 | .341 | 1.55 | 10.3 | 3.7 | 4.1 | 71.0 | 81 | 45 | 38 | 12 | 29 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.52 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 86 | 5 | 5 | 1 | 2 | 8.14 | .402 | 1.97 | 13.5 | 4.5 | 5.3 | 24.1 | 36 | 22 | 22 | 3 | 12 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.08 |
| CL | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 78 | 16 | 0 | 1 | 2 | 3.20 | .306 | 1.27 | 6.6 | 5.2 | 6.2 | 19.2 | 14 | 8 | 7 | 3 | 11 | 13 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 5.58 |
| SU | Charlton, N.Charlton, Norm >> | 32 | 1995 | L | 91 | 14 | 0 | 0 | 1 | 3.86 | .364 | 1.71 | 7.4 | 9.0 | 8.2 | 11.2 | 9 | 6 | 5 | 2 | 11 | 10 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 6.55 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 36 | 0 | 2 | 1 | 3.57 | .284 | 1.15 | 6.6 | 3.8 | 6.2 | 45.1 | 33 | 19 | 18 | 5 | 19 | 31 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.47 |
| RP | Gossage, G.Gossage, Goose >> | 26 | 1977 | R | 66 | 32 | 0 | 2 | 1 | 4.11 | .309 | 1.34 | 6.7 | 5.4 | 7.5 | 35.0 | 26 | 17 | 16 | 6 | 21 | 29 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.37 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 71 | 38 | 0 | 1 | 1 | 6.70 | .290 | 1.20 | 7.7 | 3.3 | 6.6 | 41.2 | 35 | 31 | 31 | 8 | 15 | 30 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 5.24 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 30 | 0 | 2 | 4 | 4.46 | .243 | 0.94 | 7.6 | 0.9 | 9.0 | 38.1 | 32 | 20 | 19 | 7 | 4 | 38 | 0 | 6 | 3 | 0 | 0 | 1 | 1 | 3.79 |