| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 28 | 28 | 8 | 14 | 4.42 | .309 | 1.30 | 8.4 | 3.3 | 8.4 | 183.1 | 171 | 100 | 90 | 26 | 68 | 171 | 2 | 0 | 0 | 0 | 14 | 7 | 2 | 4.21 |
| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 27 | 27 | 11 | 7 | 3.82 | .301 | 1.28 | 9.0 | 2.6 | 8.4 | 188.1 | 187 | 82 | 80 | 18 | 54 | 175 | 5 | 0 | 0 | 0 | 19 | 2 | 2 | 3.28 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 27 | 27 | 13 | 10 | 5.03 | .308 | 1.30 | 9.2 | 2.6 | 7.7 | 162.2 | 165 | 99 | 91 | 26 | 47 | 138 | 1 | 0 | 0 | 0 | 14 | 5 | 0 | 4.35 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 27 | 27 | 15 | 8 | 3.97 | .286 | 1.18 | 8.3 | 2.3 | 7.6 | 188.0 | 173 | 86 | 83 | 24 | 48 | 158 | 1 | 0 | 0 | 1 | 16 | 5 | 1 | 3.82 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 59 | 0 | 3 | 5 | 2.72 | .260 | 1.04 | 6.6 | 2.9 | 9.6 | 59.2 | 43 | 18 | 18 | 4 | 19 | 63 | 0 | 35 | 4 | 0 | 0 | 1 | 1 | 2.76 |
| RP | Treinen, B.Treinen, Blake # >> | 30 | 2018 | R | 80 | 70 | 0 | 5 | 3 | 4.48 | .301 | 1.27 | 8.4 | 3.1 | 7.5 | 70.1 | 65 | 36 | 35 | 12 | 24 | 58 | 0 | 2 | 5 | 0 | 0 | 2 | 0 | 4.69 |
| RP | Holland, G.Holland, Greg # >> | 27 | 2013 | R | 72 | 51 | 0 | 2 | 2 | 4.80 | .309 | 1.34 | 7.7 | 4.5 | 11.0 | 54.1 | 46 | 30 | 29 | 8 | 27 | 66 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.98 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 34 | 0 | 3 | 2 | 4.98 | .344 | 1.51 | 9.9 | 3.8 | 4.3 | 59.2 | 65 | 34 | 33 | 10 | 25 | 28 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 5.73 |
| SU | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 51 | 0 | 0 | 4 | 2.67 | .255 | 1.02 | 7.0 | 2.3 | 10.2 | 67.1 | 52 | 24 | 20 | 4 | 17 | 76 | 0 | 5 | 3 | 0 | 0 | 0 | 1 | 2.27 |