| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 28 | 28 | 10 | 15 | 4.70 | .316 | 1.36 | 9.2 | 3.1 | 8.8 | 185.2 | 190 | 104 | 97 | 32 | 63 | 180 | 5 | 0 | 0 | 0 | 13 | 4 | 3 | 4.39 |
| SP | Tiant, L.Tiant, Luis # >> | 28 | 1968 | R | 97 | 27 | 27 | 11 | 5 | 3.68 | .294 | 1.23 | 7.5 | 3.6 | 8.7 | 166.1 | 139 | 73 | 68 | 16 | 66 | 161 | 0 | 0 | 0 | 0 | 13 | 3 | 1 | 3.56 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 21 | 13 | 5 | 5 | 5.42 | .339 | 1.52 | 10.6 | 3.1 | 5.3 | 96.1 | 113 | 63 | 58 | 8 | 33 | 56 | 1 | 0 | 0 | 0 | 5 | 2 | 5 | 4.01 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 55 | 23 | 23 | 9 | 7 | 5.35 | .338 | 1.53 | 10.4 | 3.3 | 5.9 | 133.0 | 154 | 81 | 79 | 20 | 49 | 87 | 1 | 0 | 0 | 0 | 9 | 1 | 4 | 4.77 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 6 | 6 | 1 | 3 | 3.42 | .307 | 1.33 | 7.6 | 4.5 | 6.9 | 26.1 | 22 | 10 | 10 | 1 | 13 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.46 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 70 | 0 | 2 | 6 | 3.72 | .316 | 1.37 | 7.6 | 4.8 | 5.0 | 75.0 | 63 | 39 | 31 | 9 | 40 | 42 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 5.08 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 68 | 0 | 5 | 6 | 4.82 | .308 | 1.34 | 9.1 | 2.9 | 8.1 | 71.0 | 72 | 39 | 38 | 11 | 23 | 64 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 4.18 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 27 | 17 | 5 | 9 | 6.18 | .360 | 1.66 | 11.3 | 3.7 | 4.4 | 118.0 | 148 | 91 | 81 | 15 | 48 | 58 | 0 | 1 | 0 | 0 | 5 | 3 | 1 | 4.97 |