| SP | Tudor, J.Tudor, John-STL + >> | 34 | 1985 | L | 52 | 14 | 14 | 4 | 5 | 5.15 | .318 | 1.35 | 9.3 | 3.0 | 7.4 | 85.2 | 88 | 49 | 49 | 16 | 28 | 70 | 0 | 0 | 0 | 0 | 5 | 4 | 3 | 4.93 |
| SP | Castillo, L.Castillo, Luis # >> | 32 | 2022 | R | 51 | 12 | 12 | 2 | 5 | 6.47 | .357 | 1.65 | 10.7 | 4.1 | 10.4 | 57.0 | 68 | 41 | 41 | 8 | 26 | 66 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3.93 |
| SP | Dean, D.Dean, Dizzy-STL + >> | 22 | 1932 | R | 11 | 12 | 12 | 3 | 4 | 6.02 | .361 | 1.70 | 11.5 | 3.9 | 6.7 | 58.1 | 74 | 40 | 39 | 14 | 25 | 43 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 5.95 |
| SP | Cantillo, J.Cantillo, Joey >> | 25 | 2024 | L | 76 | 12 | 12 | 1 | 3 | 3.35 | .289 | 1.22 | 6.4 | 4.7 | 9.9 | 48.1 | 34 | 18 | 18 | 4 | 25 | 53 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.44 |
| SP | Hudson, D.Hudson, Dakota # + >> | 30 | 2022 | R | 35 | 9 | 8 | 0 | 4 | 7.25 | .349 | 1.58 | 10.0 | 4.3 | 7.8 | 36.0 | 40 | 30 | 29 | 8 | 17 | 31 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5.67 |
| CL | Helsley, R.Helsley, Ryan >> | 30 | 2022 | R | 99 | 26 | 0 | 0 | 4 | 4.43 | .287 | 1.16 | 7.8 | 2.9 | 13.1 | 22.1 | 19 | 11 | 11 | 5 | 7 | 32 | 0 | 18 | 4 | 0 | 0 | 1 | 0 | 4.14 |
| RP | Cabrera, G.Cabrera, Genesis >> | 28 | 2022 | L | 92 | 32 | 0 | 7 | 3 | 3.94 | .266 | 1.09 | 6.3 | 3.5 | 8.9 | 61.2 | 43 | 27 | 27 | 8 | 24 | 60 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 3.92 |
| RP | Romero, J.Romero, JoJo >> | 28 | 2023 | L | 91 | 32 | 0 | 3 | 1 | 5.56 | .321 | 1.37 | 8.4 | 4.2 | 10.5 | 43.2 | 40 | 27 | 27 | 10 | 20 | 50 | 0 | 0 | 3 | 0 | 0 | 2 | 2 | 5.23 |
| RP | Pallante, A.Pallante, Andre >> | 26 | 2022 | R | 47 | 24 | 0 | 3 | 1 | 3.18 | .271 | 1.06 | 6.6 | 2.9 | 7.7 | 34.0 | 25 | 13 | 12 | 4 | 11 | 29 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3.97 |
| SP | Darvish, Y.Darvish, Yu >> | 38 | 2022 | R | 32 | 1 | 1 | 0 | 0 | 4.15 | .381 | 1.85 | 13.5 | 4.5 | 4.5 | 4.1 | 6 | 2 | 2 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 51 | 11 | 0 | 1 | 1 | 2.70 | .206 | 0.78 | 5.1 | 2.3 | 11.3 | 16.2 | 9 | 5 | 5 | 1 | 4 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.06 |
| SP | Montgomery, J.Montgomery, Jordan >> | 32 | 2022 | L | 35 | 8 | 0 | 1 | 1 | 4.23 | .339 | 1.49 | 9.2 | 4.3 | 5.7 | 38.1 | 39 | 19 | 18 | 3 | 18 | 24 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.34 |
| RP | Svanson, M.Svanson, Matt >> | 26 | 2025 | R | 90 | 13 | 0 | 0 | 2 | 6.46 | .370 | 1.70 | 12.6 | 3.0 | 9.0 | 15.1 | 21 | 11 | 11 | 3 | 5 | 15 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.80 |