| SP | McLain, D.McLain, Denny-DET + >> | 27 | 1968 | R | 84 | 12 | 12 | 1 | 9 | 5.79 | .329 | 1.44 | 10.4 | 2.6 | 8.2 | 65.1 | 75 | 55 | 42 | 18 | 19 | 59 | 2 | 0 | 0 | 0 | 4 | 2 | 1 | 5.75 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2022 | L | 78 | 12 | 12 | 2 | 8 | 5.83 | .318 | 1.38 | 10.7 | 1.9 | 8.4 | 58.2 | 69 | 47 | 38 | 14 | 12 | 54 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 4.95 |
| SP | Brieske, B.Brieske, Beau >> | 27 | 2022 | R | 90 | 8 | 8 | 3 | 1 | 3.65 | .256 | 1.01 | 7.2 | 2.0 | 9.4 | 49.1 | 39 | 27 | 20 | 7 | 11 | 51 | 2 | 0 | 0 | 0 | 6 | 1 | 0 | 3.51 |
| CL | Holton, T.Holton, Tyler >> | 29 | 2023 | L | 91 | 20 | 0 | 1 | 3 | 5.22 | .254 | 1.02 | 7.1 | 2.2 | 10.2 | 29.1 | 23 | 19 | 17 | 6 | 7 | 33 | 0 | 7 | 5 | 0 | 0 | 0 | 0 | 4.14 |
| RP | Jimenez, J.Jimenez, Joe >> | 30 | 2022 | R | 63 | 29 | 0 | 0 | 1 | 5.76 | .399 | 1.99 | 13.3 | 5.0 | 10.9 | 29.2 | 43 | 30 | 19 | 4 | 16 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.03 |
| RP | Garcia, R.Garcia, Rony >> | 27 | 2022 | R | 81 | 21 | 0 | 2 | 1 | 3.94 | .284 | 1.19 | 7.9 | 2.8 | 9.8 | 32.0 | 28 | 16 | 14 | 5 | 10 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.78 |
| SP | Hurter, B.Hurter, Brant >> | 26 | 2024 | L | 84 | 4 | 0 | 1 | 1 | 5.40 | .474 | 2.70 | 9.0 | 18.0 | 12.0 | 3.1 | 3 | 2 | 2 | 1 | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10.67 |
| RP | Melton, T.Melton, Troy >> | 24 | 2025 | R | 59 | 19 | 0 | 1 | 0 | 3.53 | .296 | 1.26 | 7.2 | 4.4 | 7.5 | 35.2 | 28 | 21 | 14 | 6 | 17 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.03 |