| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 99 | 20 | 20 | 7 | 10 | 3.45 | .296 | 1.24 | 7.4 | 3.7 | 8.7 | 125.1 | 103 | 57 | 48 | 10 | 52 | 121 | 0 | 0 | 0 | 0 | 12 | 3 | 0 | 3.42 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 96 | 19 | 19 | 10 | 6 | 3.89 | .311 | 1.34 | 8.7 | 3.4 | 9.3 | 143.1 | 138 | 65 | 62 | 13 | 54 | 147 | 5 | 0 | 0 | 3 | 9 | 2 | 2 | 3.30 |
| SP | Perez, P.Perez, Pascual † # >> | 31 | 1988 | R | 88 | 19 | 19 | 11 | 4 | 3.46 | .291 | 1.21 | 8.1 | 2.8 | 6.8 | 140.1 | 126 | 56 | 54 | 11 | 44 | 105 | 4 | 0 | 0 | 2 | 12 | 3 | 7 | 3.53 |
| SP | Strasburg, S.Strasburg, Stephen >> | 24 | 2013 | R | 80 | 19 | 19 | 7 | 5 | 4.46 | .310 | 1.30 | 8.4 | 3.3 | 7.7 | 107.0 | 100 | 55 | 53 | 14 | 39 | 92 | 0 | 0 | 0 | 0 | 10 | 5 | 4 | 4.21 |
| SP | Youmans, F.Youmans, Floyd >> | 22 | 1986 | R | 66 | 18 | 18 | 9 | 1 | 3.40 | .298 | 1.26 | 6.3 | 5.1 | 6.1 | 121.2 | 85 | 49 | 46 | 12 | 68 | 82 | 1 | 0 | 0 | 1 | 12 | 2 | 7 | 4.67 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 97 | 51 | 0 | 2 | 4 | 3.43 | .291 | 1.20 | 8.4 | 2.5 | 10.0 | 65.2 | 61 | 26 | 25 | 9 | 18 | 72 | 0 | 5 | 4 | 0 | 0 | 2 | 0 | 3.51 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 85 | 40 | 0 | 5 | 1 | 2.93 | .296 | 1.24 | 6.7 | 4.5 | 8.2 | 46.0 | 34 | 15 | 15 | 4 | 23 | 42 | 0 | 3 | 5 | 0 | 0 | 1 | 1 | 3.87 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 86 | 26 | 0 | 4 | 4 | 2.62 | .237 | 0.93 | 5.0 | 3.4 | 8.5 | 34.1 | 19 | 10 | 10 | 2 | 13 | 32 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.03 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 70 | 19 | 0 | 0 | 1 | 14.34 | .500 | 2.91 | 24.3 | 3.6 | 11.7 | 10.2 | 27 | 17 | 17 | 4 | 4 | 13 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 7.10 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 67 | 14 | 0 | 1 | 0 | 4.97 | .321 | 1.34 | 6.8 | 6.0 | 9.0 | 12.2 | 9 | 7 | 7 | 1 | 8 | 12 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.33 |
| RP | Valdez, S.Valdez, Sergio >> | 28 | 1992 | R | 53 | 24 | 0 | 0 | 1 | 3.86 | .300 | 1.29 | 9.3 | 2.4 | 6.6 | 30.1 | 31 | 13 | 13 | 3 | 8 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 3.63 |