| SP | Kershaw, C.Kershaw, Clayton $$ >> | 28 | 2016 | L | 99 | 13 | 13 | 4 | 5 | 3.55 | .271 | 1.08 | 8.0 | 1.8 | 9.2 | 88.2 | 78 | 35 | 35 | 7 | 18 | 90 | 1 | 0 | 0 | 0 | 9 | 3 | 1 | 2.70 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 13 | 13 | 8 | 4 | 3.33 | .266 | 1.07 | 6.9 | 2.6 | 7.4 | 92.0 | 71 | 34 | 34 | 11 | 27 | 76 | 3 | 0 | 0 | 2 | 7 | 2 | 0 | 3.85 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 12 | 12 | 7 | 5 | 5.85 | .345 | 1.53 | 10.7 | 3.2 | 4.9 | 64.2 | 76 | 43 | 42 | 13 | 23 | 35 | 2 | 0 | 0 | 0 | 4 | 3 | 1 | 5.77 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 13 | 13 | 8 | 2 | 4.24 | .309 | 1.33 | 8.9 | 3.2 | 8.3 | 80.2 | 79 | 38 | 38 | 9 | 28 | 74 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 3.70 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 12 | 12 | 3 | 4 | 5.88 | .368 | 1.72 | 11.4 | 4.1 | 4.5 | 72.0 | 91 | 50 | 47 | 9 | 33 | 36 | 2 | 0 | 0 | 0 | 3 | 2 | 1 | 5.08 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 25 | 0 | 1 | 1 | 4.08 | .284 | 1.19 | 5.9 | 4.9 | 6.9 | 35.1 | 23 | 16 | 16 | 3 | 19 | 27 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.20 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 24 | 0 | 0 | 1 | 1.71 | .215 | 0.82 | 4.9 | 2.6 | 7.8 | 31.2 | 17 | 6 | 6 | 3 | 9 | 27 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 3.39 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 20 | 0 | 1 | 2 | 3.13 | .324 | 1.39 | 9.4 | 3.1 | 9.0 | 23.0 | 24 | 8 | 8 | 2 | 8 | 23 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.30 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 16 | 0 | 0 | 2 | 4.97 | .367 | 1.74 | 13.5 | 3.0 | 10.5 | 12.2 | 18 | 8 | 7 | 0 | 4 | 14 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 1.67 |
| SP | Newhouser, H.Newhouser, Hal >> | 25 | 1946 | L | 32 | 4 | 1 | 1 | 1 | 16.62 | .458 | 2.54 | 24.8 | 0.0 | 2.3 | 4.1 | 11 | 8 | 8 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9.00 |
| CL | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 26 | 0 | 0 | 2 | 1.69 | .238 | 0.94 | 5.1 | 3.4 | 8.5 | 37.1 | 21 | 9 | 7 | 2 | 14 | 35 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 2.95 |