| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 25 | 25 | 9 | 10 | 4.53 | .320 | 1.40 | 10.1 | 2.5 | 3.6 | 163.0 | 183 | 86 | 82 | 16 | 46 | 65 | 4 | 0 | 0 | 0 | 13 | 1 | 10 | 4.34 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 67 | 27 | 24 | 6 | 13 | 6.02 | .324 | 1.44 | 9.9 | 3.0 | 8.4 | 133.0 | 146 | 91 | 89 | 19 | 45 | 124 | 2 | 0 | 0 | 0 | 8 | 0 | 4 | 4.01 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 62 | 0 | 6 | 7 | 3.42 | .291 | 1.20 | 8.2 | 2.6 | 8.1 | 68.1 | 62 | 27 | 26 | 7 | 20 | 61 | 0 | 15 | 3 | 0 | 0 | 2 | 1 | 3.51 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 68 | 0 | 2 | 4 | 4.28 | .326 | 1.43 | 8.4 | 4.6 | 10.0 | 75.2 | 70 | 36 | 36 | 9 | 38 | 83 | 0 | 4 | 6 | 0 | 0 | 2 | 0 | 3.95 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 71 | 0 | 4 | 2 | 3.84 | .297 | 1.27 | 9.6 | 1.9 | 7.9 | 77.1 | 82 | 35 | 33 | 11 | 16 | 68 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.71 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 60 | 0 | 4 | 3 | 4.97 | .330 | 1.45 | 8.9 | 4.2 | 9.8 | 67.0 | 66 | 38 | 37 | 8 | 31 | 73 | 0 | 4 | 3 | 0 | 0 | 2 | 1 | 3.85 |
| RP | Britton, Z.Britton, Zach † >> | 28 | 2016 | L | 78 | 83 | 0 | 6 | 3 | 3.29 | .307 | 1.30 | 7.8 | 4.0 | 8.4 | 76.2 | 66 | 31 | 28 | 1 | 34 | 71 | 0 | 3 | 1 | 0 | 0 | 2 | 10 | 2.72 |