| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 12 | 6 | 3.04 | .306 | 1.28 | 8.8 | 2.7 | 9.4 | 166.0 | 162 | 59 | 56 | 16 | 50 | 173 | 1 | 0 | 0 | 1 | 17 | 8 | 0 | 3.22 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 73 | 25 | 25 | 9 | 11 | 3.84 | .295 | 1.22 | 8.8 | 2.2 | 4.7 | 204.0 | 200 | 90 | 87 | 28 | 49 | 107 | 12 | 0 | 0 | 2 | 10 | 7 | 5 | 4.56 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 25 | 25 | 7 | 15 | 5.83 | .335 | 1.50 | 10.6 | 2.9 | 4.3 | 176.0 | 208 | 118 | 114 | 24 | 56 | 84 | 6 | 0 | 0 | 0 | 8 | 2 | 3 | 4.81 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 25 | 25 | 8 | 9 | 4.12 | .331 | 1.43 | 8.5 | 4.4 | 4.0 | 155.0 | 147 | 84 | 71 | 12 | 75 | 69 | 0 | 0 | 0 | 0 | 13 | 8 | 4 | 4.72 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 62 | 0 | 2 | 1 | 1.98 | .255 | 1.00 | 5.6 | 3.4 | 8.7 | 68.1 | 42 | 18 | 15 | 2 | 26 | 66 | 0 | 5 | 3 | 0 | 0 | 2 | 0 | 2.68 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 49 | 0 | 4 | 5 | 4.55 | .333 | 1.48 | 10.4 | 3.1 | 8.5 | 59.1 | 68 | 31 | 30 | 9 | 20 | 56 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 4.15 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 65 | 46 | 0 | 5 | 5 | 3.35 | .264 | 1.08 | 6.9 | 2.8 | 6.2 | 51.0 | 39 | 19 | 19 | 6 | 16 | 35 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 4.10 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 30 | 0 | 2 | 2 | 5.23 | .319 | 1.38 | 9.0 | 3.7 | 10.4 | 32.2 | 32 | 19 | 19 | 4 | 13 | 37 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 3.63 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 11 | 0 | 0 | 2 | 3.60 | .338 | 1.53 | 9.0 | 4.8 | 4.8 | 15.0 | 15 | 7 | 6 | 2 | 8 | 8 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 5.27 |