| SP | Galarraga, A.Galarraga, Armando >> | 26 | 2008 | R | 81 | 34 | 33 | 11 | 5 | 3.47 | .303 | 1.27 | 7.8 | 3.7 | 5.9 | 184.1 | 159 | 74 | 71 | 24 | 75 | 120 | 0 | 1 | 0 | 0 | 11 | 6 | 4 | 4.71 |
| SP | Maddux, G.Maddux, Greg >> | 42 | 2008 | R | 47 | 33 | 14 | 7 | 5 | 4.78 | .327 | 1.42 | 10.4 | 2.4 | 5.4 | 139.1 | 161 | 74 | 74 | 20 | 37 | 84 | 0 | 1 | 0 | 0 | 6 | 5 | 3 | 4.57 |
| CL | Carlson, J.Carlson, Jesse † >> | 28 | 2008 | L | 90 | 64 | 0 | 5 | 8 | 3.15 | .289 | 1.22 | 7.1 | 4.0 | 6.6 | 65.2 | 51 | 23 | 23 | 8 | 29 | 48 | 0 | 33 | 7 | 0 | 0 | 0 | 0 | 4.46 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 28 | 2008 | R | 82 | 71 | 0 | 3 | 3 | 4.28 | .299 | 1.26 | 9.6 | 1.8 | 9.6 | 75.2 | 80 | 37 | 36 | 3 | 15 | 80 | 0 | 1 | 3 | 0 | 0 | 2 | 2 | 2.07 |
| RP | Valverde, J.Valverde, Jose >> | 29 | 2008 | R | 66 | 47 | 0 | 6 | 5 | 3.70 | .308 | 1.32 | 8.6 | 3.4 | 9.4 | 48.2 | 46 | 23 | 20 | 7 | 18 | 50 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.00 |
| RP | Oliver, D.Oliver, Darren >> | 38 | 2008 | L | 50 | 103 | 0 | 2 | 1 | 3.94 | .318 | 1.38 | 9.8 | 2.6 | 6.1 | 80.0 | 87 | 37 | 35 | 5 | 23 | 54 | 0 | 1 | 0 | 0 | 0 | 2 | 7 | 3.40 |
| SP | Danks, J.Danks, John # >> | 23 | 2008 | L | 70 | 35 | 17 | 1 | 13 | 7.15 | .360 | 1.66 | 12.1 | 2.9 | 6.8 | 118.1 | 159 | 95 | 94 | 21 | 38 | 89 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 4.85 |