| SP | Kuroda, H.Kuroda, Hiroki >> | 33 | 2008 | R | 59 | 23 | 23 | 4 | 9 | 5.54 | .323 | 1.41 | 10.1 | 2.6 | 5.4 | 112.0 | 126 | 69 | 69 | 21 | 32 | 67 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 5.15 |
| SP | Lackey, J.Lackey, John # >> | 30 | 2008 | R | 58 | 22 | 22 | 6 | 10 | 5.15 | .333 | 1.46 | 10.6 | 2.7 | 6.8 | 127.2 | 149 | 79 | 73 | 19 | 38 | 96 | 1 | 0 | 0 | 0 | 11 | 4 | 6 | 4.43 |
| SP | Sanchez, J.Sanchez, Jonathan >> | 26 | 2008 | L | 30 | 21 | 21 | 8 | 6 | 5.68 | .349 | 1.57 | 10.2 | 3.9 | 8.3 | 101.1 | 115 | 65 | 64 | 11 | 44 | 93 | 0 | 0 | 0 | 0 | 5 | 4 | 1 | 4.00 |
| RP | Buchholz, T.Buchholz, Taylor >> | 27 | 2008 | R | 91 | 72 | 0 | 5 | 2 | 3.39 | .310 | 1.32 | 8.0 | 3.9 | 5.5 | 69.0 | 61 | 26 | 26 | 5 | 30 | 42 | 0 | 3 | 3 | 0 | 0 | 2 | 5 | 4.12 |
| RP | Jenks, B.Jenks, Bobby # >> | 27 | 2008 | R | 62 | 57 | 0 | 4 | 2 | 6.55 | .369 | 1.71 | 10.2 | 5.2 | 5.9 | 67.1 | 76 | 49 | 49 | 10 | 39 | 44 | 0 | 4 | 4 | 0 | 0 | 3 | 5 | 5.51 |
| RP | Durbin, C.Durbin, Chad >> | 31 | 2008 | R | 27 | 50 | 0 | 3 | 7 | 4.55 | .344 | 1.54 | 9.3 | 4.6 | 5.9 | 55.1 | 57 | 31 | 28 | 10 | 28 | 36 | 0 | 7 | 2 | 0 | 0 | 2 | 0 | 5.69 |
| SP | Moehler, B.Moehler, Brian >> | 37 | 2008 | R | 18 | 39 | 1 | 3 | 5 | 5.77 | .382 | 1.84 | 12.0 | 4.7 | 6.0 | 57.2 | 76 | 38 | 37 | 13 | 30 | 38 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 6.26 |