| SP | Chamberlain, J.Chamberlain, Joba >> | 23 | 2008 | R | 77 | 4 | 4 | 0 | 1 | 5.40 | .359 | 1.68 | 9.0 | 6.8 | 5.6 | 8.1 | 8 | 5 | 5 | 1 | 6 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.63 |
| SP | Greinke, Z.Greinke, Zack >> | 25 | 2008 | R | 53 | 4 | 4 | 0 | 2 | 5.87 | .349 | 1.61 | 9.8 | 4.7 | 6.3 | 23.0 | 25 | 15 | 15 | 4 | 12 | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 5.43 |
| SP | Perez, O.Perez, Oliver >> | 27 | 2008 | L | 48 | 4 | 4 | 1 | 1 | 5.59 | .348 | 1.55 | 9.9 | 4.3 | 8.1 | 19.1 | 21 | 14 | 12 | 4 | 9 | 17 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 5.53 |
| SP | Vazquez, J.Vazquez, Javier >> | 32 | 2008 | R | 40 | 4 | 4 | 0 | 2 | 4.28 | .268 | 1.06 | 7.7 | 2.0 | 7.7 | 27.1 | 23 | 14 | 13 | 4 | 6 | 23 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 4.00 |
| RP | Buchholz, T.Buchholz, Taylor >> | 27 | 2008 | R | 91 | 11 | 0 | 1 | 2 | 5.54 | .291 | 1.23 | 9.0 | 2.1 | 9.0 | 13.0 | 13 | 8 | 8 | 3 | 3 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.69 |
| RP | Masterson, J.Masterson, Justin >> | 23 | 2008 | R | 57 | 10 | 0 | 1 | 2 | 4.74 | .313 | 1.37 | 8.5 | 3.8 | 7.6 | 19.0 | 18 | 10 | 10 | 1 | 8 | 16 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.26 |
| RP | Guardado, E.Guardado, Eddie >> | 38 | 2008 | L | 40 | 8 | 0 | 1 | 0 | 4.97 | .240 | 0.87 | 6.8 | 1.5 | 7.5 | 12.2 | 9 | 7 | 7 | 0 | 2 | 10 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.08 |
| RP | Durbin, C.Durbin, Chad >> | 31 | 2008 | R | 27 | 6 | 0 | 0 | 0 | 5.87 | .378 | 1.83 | 5.1 | 12.9 | 5.1 | 7.2 | 4 | 5 | 5 | 1 | 10 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 8.00 |
| SP | Sanchez, J.Sanchez, Jonathan >> | 26 | 2008 | L | 30 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Verlander, J.Verlander, Justin >> | 25 | 2008 | R | 32 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Moehler, B.Moehler, Brian >> | 37 | 2008 | R | 18 | 6 | 0 | 1 | 0 | 0.00 | .227 | 0.88 | 6.5 | 1.6 | 8.2 | 11.1 | 8 | 0 | 0 | 0 | 2 | 10 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1.73 |