| SP | Santana, J.Santana, Johan >> | 29 | 2008 | L | 93 | 25 | 25 | 7 | 7 | 3.31 | .282 | 1.14 | 8.1 | 2.2 | 6.5 | 166.0 | 149 | 65 | 61 | 19 | 41 | 120 | 0 | 0 | 0 | 0 | 17 | 6 | 4 | 3.89 |
| SP | Rodriguez, W.Rodriguez, Wandy >> | 29 | 2008 | L | 44 | 24 | 24 | 6 | 7 | 4.15 | .324 | 1.40 | 8.9 | 3.8 | 6.8 | 125.2 | 123 | 61 | 58 | 21 | 53 | 94 | 0 | 0 | 0 | 0 | 4 | 5 | 1 | 5.07 |
| SP | Vazquez, J.Vazquez, Javier # >> | 32 | 2008 | R | 40 | 24 | 24 | 12 | 6 | 4.33 | .318 | 1.37 | 9.5 | 2.9 | 7.5 | 139.1 | 146 | 68 | 67 | 22 | 45 | 116 | 1 | 0 | 0 | 0 | 13 | 4 | 2 | 4.45 |
| SP | Jimenez, U.Jimenez, Ubaldo >> | 24 | 2008 | R | 37 | 23 | 23 | 4 | 6 | 5.98 | .385 | 1.83 | 10.8 | 5.7 | 7.4 | 114.1 | 137 | 76 | 76 | 19 | 72 | 94 | 0 | 0 | 0 | 0 | 4 | 6 | 8 | 5.57 |
| SP | Hernandez, F.Hernandez, Felix >> | 22 | 2008 | R | 31 | 23 | 23 | 7 | 8 | 5.19 | .352 | 1.59 | 11.1 | 3.3 | 7.1 | 126.2 | 155 | 77 | 73 | 21 | 46 | 99 | 0 | 0 | 0 | 0 | 10 | 5 | 3 | 4.81 |
| RP | Bruney, B.Bruney, Brian >> | 26 | 2008 | R | 93 | 64 | 0 | 5 | 4 | 2.71 | .268 | 1.10 | 5.4 | 4.5 | 6.7 | 93.0 | 56 | 29 | 28 | 8 | 46 | 69 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 4.12 |
| RP | Oliver, D.Oliver, Darren >> | 38 | 2008 | L | 50 | 62 | 0 | 7 | 4 | 4.63 | .325 | 1.37 | 8.6 | 3.8 | 5.2 | 91.1 | 87 | 47 | 47 | 6 | 38 | 53 | 0 | 6 | 4 | 0 | 0 | 7 | 6 | 4.18 |
| RP | Hanrahan, J.Hanrahan, Joel # >> | 27 | 2008 | R | 38 | 59 | 0 | 4 | 6 | 6.06 | .337 | 1.46 | 10.0 | 3.2 | 8.6 | 62.1 | 69 | 43 | 42 | 10 | 22 | 59 | 0 | 9 | 9 | 0 | 0 | 4 | 4 | 4.45 |
| RP | Durbin, C.Durbin, Chad >> | 31 | 2008 | R | 27 | 54 | 0 | 4 | 7 | 6.00 | .317 | 1.38 | 9.0 | 3.4 | 6.5 | 69.0 | 69 | 47 | 46 | 8 | 26 | 50 | 0 | 3 | 4 | 0 | 0 | 1 | 3 | 4.23 |
| SP | Baek, C.Baek, Cha Seung >> | 28 | 2008 | R | 29 | 6 | 0 | 0 | 0 | 1.93 | .391 | 1.93 | 13.5 | 6.8 | 4.5 | 4.2 | 6 | 1 | 1 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.25 |
| SP | Moehler, B.Moehler, Brian >> | 37 | 2008 | R | 18 | 40 | 0 | 1 | 7 | 6.07 | .392 | 1.92 | 12.9 | 4.5 | 5.5 | 56.1 | 80 | 44 | 38 | 10 | 28 | 34 | 0 | 5 | 2 | 0 | 0 | 1 | 4 | 5.66 |