| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 100 | 5 | 5 | 2 | 1 | 2.60 | .257 | 1.01 | 6.9 | 2.4 | 8.2 | 34.2 | 26 | 10 | 10 | 3 | 9 | 31 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3.21 |
| SP | Saunders, J.Saunders, Joe >> | 27 | 2008 | L | 65 | 4 | 4 | 1 | 2 | 4.63 | .346 | 1.59 | 9.4 | 5.1 | 3.9 | 23.1 | 24 | 15 | 12 | 5 | 13 | 10 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 6.65 |
| CL | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 96 | 12 | 0 | 1 | 1 | 1.35 | .216 | 0.83 | 6.2 | 1.4 | 11.8 | 13.1 | 9 | 2 | 2 | 0 | 2 | 17 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0.85 |
| RP | Francisco, F.Francisco, Frank >> | 29 | 2008 | R | 80 | 10 | 0 | 1 | 0 | 4.15 | .350 | 1.62 | 10.1 | 5.6 | 14.6 | 8.2 | 9 | 4 | 4 | 2 | 5 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.88 |
| RP | Springer, R.Springer, Russ >> | 40 | 2008 | R | 74 | 9 | 0 | 0 | 2 | 9.00 | .400 | 2.00 | 12.6 | 5.4 | 2.7 | 10.0 | 14 | 10 | 10 | 5 | 6 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 10.70 |
| SP | Mussina, M.Mussina, Mike >> | 40 | 2008 | R | 50 | 3 | 0 | 0 | 2 | 16.50 | .526 | 3.17 | 24.0 | 4.5 | 6.0 | 6.0 | 16 | 11 | 11 | 2 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 8.00 |