| SP | Marcum, S.Marcum, Shaun † >> | 27 | 2008 | R | 92 | 24 | 24 | 8 | 8 | 4.06 | .321 | 1.39 | 8.9 | 3.6 | 6.7 | 146.1 | 145 | 75 | 66 | 19 | 59 | 109 | 0 | 0 | 0 | 0 | 13 | 4 | 1 | 4.49 |
| SP | Slowey, K.Slowey, Kevin >> | 24 | 2008 | R | 69 | 23 | 23 | 8 | 8 | 5.73 | .343 | 1.54 | 11.3 | 2.5 | 8.6 | 113.0 | 142 | 72 | 72 | 19 | 32 | 108 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 4.20 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke # >> | 28 | 2008 | R | 68 | 22 | 22 | 6 | 6 | 5.45 | .342 | 1.51 | 9.4 | 4.3 | 6.0 | 112.1 | 117 | 68 | 68 | 14 | 53 | 75 | 0 | 0 | 0 | 0 | 2 | 5 | 3 | 4.84 |
| SP | Sonnanstine, A.Sonnanstine, Andy >> | 25 | 2008 | R | 36 | 22 | 22 | 5 | 12 | 5.68 | .341 | 1.52 | 10.5 | 3.3 | 5.9 | 126.2 | 147 | 81 | 80 | 19 | 46 | 83 | 0 | 0 | 0 | 0 | 8 | 4 | 3 | 4.83 |
| RP | Wagner, B.Wagner, Billy >> | 37 | 2008 | L | 94 | 58 | 0 | 4 | 3 | 3.01 | .276 | 1.12 | 6.8 | 3.3 | 8.8 | 92.2 | 70 | 32 | 31 | 4 | 34 | 90 | 0 | 1 | 1 | 0 | 0 | 2 | 4 | 2.78 |
| RP | Oliver, D.Oliver, Darren >> | 38 | 2008 | L | 50 | 57 | 0 | 7 | 3 | 2.65 | .250 | 0.96 | 6.5 | 2.2 | 5.3 | 78.0 | 56 | 23 | 23 | 6 | 19 | 46 | 0 | 8 | 2 | 0 | 0 | 3 | 4 | 3.67 |
| RP | Sampson, C.Sampson, Chris >> | 30 | 2008 | R | 36 | 40 | 0 | 2 | 2 | 6.08 | .337 | 1.49 | 10.1 | 3.4 | 7.3 | 63.2 | 71 | 43 | 43 | 11 | 24 | 51 | 0 | 4 | 0 | 0 | 0 | 2 | 0 | 4.89 |
| RP | Grilli, J.Grilli, Jason >> | 32 | 2008 | R | 25 | 34 | 0 | 0 | 3 | 3.14 | .291 | 1.23 | 7.3 | 3.8 | 6.1 | 43.0 | 35 | 16 | 15 | 2 | 18 | 29 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.51 |
| SP | Harang, A.Harang, Aaron >> | 30 | 2008 | R | 15 | 2 | 0 | 1 | 0 | 2.70 | .286 | 0.90 | 9.0 | 0.0 | 0.0 | 3.1 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 8.33 |
| SP | Johnson, J.Johnson, Josh >> | 24 | 2008 | R | 28 | 16 | 0 | 3 | 2 | 5.72 | .370 | 1.73 | 11.9 | 3.9 | 6.4 | 28.1 | 37 | 18 | 18 | 4 | 12 | 20 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 4.82 |