| SP | Nolasco, R.Nolasco, Ricky † >> | 26 | 2008 | R | 94 | 25 | 25 | 11 | 8 | 3.43 | .270 | 1.09 | 7.7 | 2.1 | 6.3 | 173.0 | 148 | 69 | 66 | 22 | 40 | 122 | 0 | 0 | 0 | 0 | 16 | 4 | 2 | 4.01 |
| SP | Perez, O.Perez, Oliver >> | 27 | 2008 | L | 48 | 24 | 24 | 6 | 6 | 4.03 | .308 | 1.28 | 7.4 | 4.2 | 6.6 | 127.1 | 104 | 61 | 57 | 11 | 59 | 93 | 0 | 0 | 0 | 0 | 4 | 7 | 6 | 4.22 |
| SP | Maddux, G.Maddux, Greg # >> | 42 | 2008 | R | 47 | 24 | 24 | 1 | 13 | 5.90 | .316 | 1.39 | 10.0 | 2.5 | 5.1 | 122.0 | 135 | 82 | 80 | 22 | 34 | 69 | 0 | 0 | 0 | 0 | 9 | 0 | 2 | 5.05 |
| SP | Lannan, J.Lannan, John >> | 24 | 2008 | L | 39 | 23 | 23 | 5 | 7 | 6.51 | .339 | 1.47 | 9.2 | 4.1 | 5.5 | 113.1 | 116 | 83 | 82 | 23 | 51 | 69 | 0 | 0 | 0 | 0 | 5 | 7 | 10 | 5.96 |
| SP | Lohse, K.Lohse, Kyle # >> | 30 | 2008 | R | 35 | 21 | 21 | 5 | 7 | 5.12 | .319 | 1.37 | 10.1 | 2.2 | 6.4 | 130.0 | 146 | 75 | 74 | 21 | 32 | 92 | 0 | 0 | 0 | 0 | 10 | 5 | 3 | 4.54 |
| RP | Wagner, B.Wagner, Billy >> | 37 | 2008 | L | 94 | 65 | 0 | 6 | 6 | 4.42 | .294 | 1.22 | 8.5 | 2.5 | 8.6 | 93.2 | 88 | 46 | 46 | 12 | 26 | 89 | 0 | 8 | 4 | 0 | 0 | 3 | 2 | 3.70 |
| RP | Walker, T.Walker, Tyler >> | 32 | 2008 | R | 41 | 55 | 0 | 6 | 5 | 5.32 | .341 | 1.51 | 8.4 | 5.2 | 5.8 | 71.0 | 66 | 45 | 42 | 14 | 41 | 46 | 0 | 8 | 3 | 0 | 0 | 3 | 3 | 6.13 |
| RP | Billingsley, C.Billingsley, Chad >> | 24 | 2008 | R | 31 | 45 | 0 | 2 | 5 | 3.63 | .271 | 1.10 | 7.1 | 2.9 | 9.6 | 91.2 | 72 | 39 | 37 | 10 | 29 | 97 | 0 | 8 | 2 | 0 | 0 | 1 | 5 | 3.29 |
| RP | Torres, S.Torres, Salomon >> | 36 | 2008 | R | 20 | 24 | 0 | 1 | 2 | 4.40 | .328 | 1.47 | 10.2 | 3.3 | 5.7 | 30.2 | 34 | 15 | 15 | 4 | 11 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.57 |
| SP | Verlander, J.Verlander, Justin >> | 25 | 2008 | R | 32 | 3 | 2 | 0 | 2 | 9.53 | .382 | 1.68 | 12.3 | 3.3 | 5.7 | 11.1 | 15 | 12 | 12 | 1 | 4 | 7 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 4.55 |
| SP | McGowan, D.McGowan, Dustin >> | 26 | 2008 | R | 22 | 12 | 0 | 1 | 2 | 4.68 | .330 | 1.48 | 9.0 | 4.3 | 6.8 | 25.0 | 25 | 13 | 13 | 3 | 12 | 19 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.48 |