| SP | Santana, E.Santana, Ervin † >> | 25 | 2008 | R | 96 | 34 | 34 | 14 | 12 | 3.94 | .295 | 1.24 | 8.6 | 2.6 | 7.9 | 214.2 | 204 | 95 | 94 | 35 | 62 | 188 | 1 | 0 | 0 | 1 | 19 | 3 | 4 | 4.28 |
| SP | Wellemeyer, T.Wellemeyer, Todd >> | 30 | 2008 | R | 61 | 32 | 32 | 11 | 13 | 5.18 | .345 | 1.54 | 10.3 | 3.6 | 5.9 | 158.0 | 181 | 96 | 91 | 29 | 63 | 103 | 0 | 0 | 0 | 0 | 6 | 6 | 2 | 5.39 |
| SP | Perez, O.Perez, Oliver >> | 27 | 2008 | L | 48 | 32 | 32 | 10 | 12 | 4.54 | .327 | 1.41 | 8.7 | 4.0 | 6.5 | 158.2 | 153 | 88 | 80 | 19 | 70 | 114 | 0 | 0 | 0 | 0 | 9 | 8 | 3 | 4.60 |
| SP | Maholm, P.Maholm, Paul # >> | 26 | 2008 | L | 46 | 30 | 30 | 12 | 9 | 4.69 | .330 | 1.43 | 10.0 | 2.9 | 5.2 | 178.1 | 198 | 94 | 93 | 22 | 57 | 103 | 0 | 0 | 0 | 0 | 16 | 8 | 1 | 4.54 |
| RP | Springer, R.Springer, Russ >> | 40 | 2008 | R | 74 | 87 | 0 | 6 | 6 | 2.65 | .268 | 1.07 | 6.3 | 3.3 | 7.6 | 132.1 | 93 | 42 | 39 | 10 | 48 | 112 | 0 | 8 | 6 | 0 | 0 | 4 | 6 | 3.47 |
| RP | Walker, T.Walker, Tyler >> | 32 | 2008 | R | 41 | 65 | 0 | 5 | 6 | 5.59 | .337 | 1.49 | 8.1 | 5.4 | 6.2 | 77.1 | 69 | 53 | 48 | 16 | 46 | 53 | 0 | 6 | 3 | 0 | 0 | 3 | 6 | 6.23 |
| RP | Affeldt, J.Affeldt, Jeremy >> | 29 | 2008 | L | 30 | 63 | 0 | 3 | 0 | 5.49 | .340 | 1.52 | 10.3 | 3.4 | 8.6 | 77.0 | 88 | 47 | 47 | 12 | 29 | 74 | 0 | 4 | 3 | 0 | 0 | 2 | 2 | 4.31 |
| SP | Hernandez, F.Hernandez, Felix >> | 22 | 2008 | R | 31 | 4 | 0 | 0 | 0 | 0.00 | .154 | 0.27 | 3.0 | 0.0 | 3.0 | 3.2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.33 |
| SP | Jimenez, U.Jimenez, Ubaldo >> | 24 | 2008 | R | 37 | 34 | 0 | 4 | 4 | 5.74 | .368 | 1.74 | 9.8 | 5.9 | 8.3 | 53.1 | 58 | 34 | 34 | 6 | 35 | 49 | 0 | 4 | 0 | 0 | 0 | 0 | 7 | 4.60 |