| SP | Nolasco, R.Nolasco, Ricky † >> | 26 | 2008 | R | 94 | 23 | 23 | 10 | 3 | 2.49 | .264 | 1.05 | 7.6 | 1.9 | 6.0 | 166.0 | 140 | 47 | 46 | 15 | 35 | 111 | 2 | 0 | 0 | 0 | 20 | 4 | 0 | 3.54 |
| SP | Perez, O.Perez, Oliver # >> | 27 | 2008 | L | 48 | 22 | 22 | 8 | 6 | 5.10 | .316 | 1.35 | 8.4 | 3.8 | 7.1 | 120.0 | 112 | 71 | 68 | 16 | 50 | 95 | 0 | 0 | 0 | 0 | 6 | 4 | 5 | 4.50 |
| SP | Litsch, J.Litsch, Jesse >> | 23 | 2008 | R | 43 | 22 | 22 | 7 | 9 | 5.87 | .341 | 1.55 | 11.9 | 2.1 | 6.2 | 127.1 | 168 | 88 | 83 | 19 | 29 | 87 | 0 | 0 | 0 | 0 | 7 | 1 | 2 | 4.28 |
| RP | Qualls, C.Qualls, Chad >> | 30 | 2008 | R | 76 | 52 | 0 | 5 | 3 | 4.81 | .357 | 1.63 | 10.5 | 4.3 | 7.7 | 67.1 | 78 | 40 | 36 | 10 | 32 | 57 | 0 | 2 | 6 | 0 | 0 | 2 | 1 | 4.76 |
| RP | Masterson, J.Masterson, Justin # >> | 23 | 2008 | R | 57 | 49 | 0 | 4 | 8 | 5.40 | .324 | 1.42 | 9.0 | 3.8 | 6.1 | 85.0 | 85 | 52 | 51 | 16 | 36 | 58 | 0 | 7 | 4 | 0 | 0 | 1 | 2 | 5.39 |
| RP | Walker, T.Walker, Tyler >> | 32 | 2008 | R | 41 | 36 | 0 | 5 | 0 | 3.27 | .275 | 1.14 | 7.0 | 3.3 | 7.0 | 41.1 | 32 | 15 | 15 | 3 | 15 | 32 | 0 | 8 | 2 | 0 | 0 | 0 | 2 | 3.49 |
| RP | Affeldt, J.Affeldt, Jeremy >> | 29 | 2008 | L | 30 | 32 | 0 | 0 | 0 | 2.97 | .301 | 1.29 | 8.8 | 3.0 | 8.0 | 36.1 | 35 | 12 | 12 | 4 | 12 | 32 | 0 | 3 | 0 | 0 | 0 | 0 | 5 | 3.67 |
| SP | Buehrle, M.Buehrle, Mark >> | 29 | 2008 | L | 21 | 8 | 0 | 0 | 4 | 5.89 | .375 | 1.80 | 13.5 | 3.0 | 8.5 | 18.1 | 27 | 12 | 12 | 4 | 6 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.00 |