| SP | Halladay, R.Halladay, Roy >> | 31 | 2008 | R | 95 | 5 | 5 | 2 | 2 | 3.35 | .315 | 1.33 | 8.8 | 3.4 | 6.6 | 37.2 | 36 | 14 | 14 | 3 | 14 | 27 | 1 | 0 | 0 | 0 | 4 | 2 | 0 | 3.89 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 68 | 4 | 4 | 3 | 1 | 3.38 | .265 | 1.08 | 6.4 | 3.4 | 6.0 | 24.0 | 17 | 9 | 9 | 2 | 9 | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.88 |
| SP | Lannan, J.Lannan, John >> | 24 | 2008 | L | 39 | 4 | 4 | 1 | 2 | 8.27 | .367 | 1.69 | 10.8 | 5.0 | 6.3 | 20.2 | 24 | 19 | 19 | 8 | 11 | 14 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 8.60 |
| RP | Bruney, B.Bruney, Brian >> | 26 | 2008 | R | 93 | 11 | 0 | 1 | 1 | 1.65 | .222 | 0.80 | 3.9 | 3.4 | 7.9 | 16.1 | 7 | 3 | 3 | 0 | 6 | 14 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 2.56 |
| RP | Carlyle, B.Carlyle, Buddy >> | 31 | 2008 | R | 47 | 10 | 0 | 1 | 0 | 5.93 | .328 | 1.46 | 8.3 | 5.5 | 9.0 | 13.2 | 12 | 9 | 9 | 2 | 8 | 13 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.85 |
| RP | Shields, S.Shields, Scot >> | 33 | 2008 | R | 35 | 8 | 0 | 0 | 0 | 9.95 | .457 | 2.53 | 16.5 | 7.5 | 9.0 | 6.1 | 11 | 7 | 7 | 1 | 5 | 6 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.67 |
| RP | Grilli, J.Grilli, Jason >> | 32 | 2008 | R | 25 | 5 | 0 | 0 | 0 | 4.26 | .321 | 1.42 | 3.0 | 10.5 | 10.5 | 6.1 | 2 | 3 | 3 | 0 | 7 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.17 |
| SP | Looper, B.Looper, Braden >> | 34 | 2008 | R | 27 | 2 | 0 | 0 | 0 | 7.36 | .389 | 1.64 | 18.0 | 0.0 | 9.0 | 3.2 | 6 | 3 | 3 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 6.33 |