| SP | Hamels, C.Hamels, Cole † >> | 25 | 2008 | L | 100 | 25 | 25 | 9 | 9 | 2.77 | .262 | 1.04 | 6.6 | 2.7 | 6.0 | 172.1 | 127 | 57 | 53 | 21 | 52 | 115 | 1 | 0 | 0 | 0 | 18 | 5 | 0 | 4.24 |
| SP | Wellemeyer, T.Wellemeyer, Todd >> | 30 | 2008 | R | 61 | 24 | 24 | 6 | 13 | 7.45 | .333 | 1.47 | 9.9 | 3.4 | 5.5 | 108.2 | 119 | 93 | 90 | 24 | 41 | 66 | 0 | 0 | 0 | 0 | 6 | 3 | 4 | 5.89 |
| SP | Kuroda, H.Kuroda, Hiroki >> | 33 | 2008 | R | 59 | 23 | 23 | 5 | 12 | 6.32 | .362 | 1.66 | 11.9 | 3.0 | 5.6 | 104.0 | 138 | 74 | 73 | 15 | 35 | 65 | 0 | 0 | 0 | 0 | 4 | 4 | 5 | 4.75 |
| SP | Mussina, M.Mussina, Mike >> | 40 | 2008 | R | 50 | 24 | 23 | 11 | 6 | 4.17 | .297 | 1.26 | 9.4 | 1.9 | 6.7 | 127.1 | 133 | 59 | 59 | 19 | 27 | 95 | 0 | 0 | 0 | 0 | 10 | 1 | 2 | 4.11 |
| CL | Romo, S.Romo, Sergio † >> | 25 | 2008 | R | 97 | 60 | 0 | 3 | 5 | 2.25 | .242 | 0.94 | 6.1 | 2.4 | 5.4 | 68.0 | 46 | 19 | 17 | 6 | 18 | 41 | 0 | 26 | 3 | 0 | 0 | 1 | 0 | 3.78 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 26 | 2008 | R | 81 | 75 | 0 | 2 | 1 | 2.79 | .307 | 1.32 | 7.2 | 4.7 | 7.1 | 77.1 | 62 | 26 | 24 | 7 | 40 | 61 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.19 |
| RP | Qualls, C.Qualls, Chad >> | 30 | 2008 | R | 76 | 75 | 0 | 2 | 1 | 2.62 | .272 | 1.09 | 7.3 | 2.6 | 8.6 | 68.2 | 55 | 22 | 20 | 7 | 20 | 65 | 0 | 4 | 1 | 0 | 0 | 2 | 6 | 3.40 |
| RP | Okajima, H.Okajima, Hideki >> | 33 | 2008 | L | 70 | 81 | 0 | 3 | 1 | 1.44 | .245 | 0.96 | 5.8 | 2.9 | 8.0 | 75.0 | 48 | 15 | 12 | 3 | 24 | 67 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 2.73 |
| RP | Perez, R.Perez, Rafael >> | 26 | 2008 | L | 60 | 66 | 0 | 4 | 3 | 3.92 | .313 | 1.34 | 8.2 | 3.9 | 9.7 | 64.1 | 58 | 30 | 28 | 4 | 28 | 69 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 3.06 |
| SP | Litsch, J.Litsch, Jesse >> | 23 | 2008 | R | 43 | 23 | 0 | 2 | 3 | 3.76 | .307 | 1.28 | 8.8 | 2.9 | 8.6 | 40.2 | 39 | 17 | 17 | 7 | 13 | 38 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 4.50 |