| SP | Lincecum, T.Lincecum, Tim # >> | 24 | 2008 | R | 97 | 35 | 35 | 14 | 16 | 4.10 | .303 | 1.26 | 7.7 | 3.7 | 9.2 | 217.1 | 185 | 101 | 99 | 22 | 89 | 222 | 0 | 0 | 0 | 0 | 20 | 9 | 9 | 3.63 |
| SP | Chamberlain, J.Chamberlain, Joba # >> | 23 | 2008 | R | 77 | 34 | 34 | 0 | 13 | 4.99 | .331 | 1.47 | 9.5 | 3.7 | 9.4 | 83.0 | 88 | 46 | 46 | 10 | 34 | 87 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.73 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 68 | 33 | 33 | 6 | 13 | 5.23 | .367 | 1.69 | 9.7 | 5.6 | 6.4 | 165.1 | 177 | 100 | 96 | 19 | 102 | 117 | 0 | 0 | 0 | 0 | 5 | 9 | 3 | 5.10 |
| SP | Weaver, J.Weaver, Jered >> | 26 | 2008 | R | 54 | 33 | 33 | 9 | 11 | 5.49 | .339 | 1.50 | 10.5 | 3.0 | 6.9 | 172.0 | 201 | 108 | 105 | 24 | 57 | 131 | 0 | 0 | 0 | 0 | 7 | 7 | 2 | 4.41 |
| SP | Mussina, M.Mussina, Mike † >> | 40 | 2008 | R | 50 | 31 | 31 | 17 | 5 | 4.12 | .314 | 1.34 | 9.6 | 2.6 | 5.8 | 172.2 | 183 | 80 | 79 | 26 | 49 | 111 | 0 | 0 | 0 | 0 | 14 | 5 | 2 | 4.62 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 96 | 86 | 0 | 13 | 1 | 3.24 | .272 | 1.09 | 6.3 | 3.6 | 6.3 | 144.2 | 100 | 55 | 52 | 12 | 58 | 100 | 0 | 2 | 4 | 0 | 0 | 4 | 1 | 3.99 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 26 | 2008 | R | 81 | 85 | 0 | 8 | 5 | 4.04 | .306 | 1.31 | 7.5 | 4.4 | 7.0 | 124.2 | 103 | 61 | 56 | 13 | 60 | 96 | 0 | 7 | 6 | 0 | 0 | 2 | 0 | 4.31 |
| RP | Ziegler, B.Ziegler, Brad >> | 29 | 2008 | R | 59 | 86 | 0 | 4 | 7 | 3.61 | .314 | 1.32 | 7.2 | 4.7 | 5.8 | 117.1 | 94 | 49 | 47 | 11 | 61 | 75 | 0 | 8 | 1 | 0 | 0 | 6 | 0 | 4.66 |
| RP | Wright, W.Wright, Wesley >> | 23 | 2008 | L | 34 | 66 | 0 | 4 | 3 | 4.25 | .308 | 1.31 | 7.5 | 4.3 | 10.3 | 89.0 | 74 | 42 | 42 | 15 | 43 | 102 | 0 | 4 | 1 | 0 | 0 | 2 | 1 | 4.42 |
| SP | Looper, B.Looper, Braden >> | 34 | 2008 | R | 27 | 1 | 0 | 0 | 0 | 0.00 | .167 | 0.60 | 9.0 | 0.0 | 9.0 | 1.2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 |
| SP | Lannan, J.Lannan, John >> | 24 | 2008 | L | 39 | 49 | 0 | 0 | 7 | 3.61 | .354 | 1.65 | 10.8 | 4.1 | 6.5 | 72.1 | 86 | 30 | 29 | 10 | 33 | 52 | 0 | 11 | 1 | 0 | 0 | 0 | 2 | 4.74 |