| SP | Sabathia, C.Sabathia, CC >> | 28 | 2008 | L | 98 | 31 | 31 | 13 | 11 | 4.02 | .313 | 1.35 | 9.4 | 2.8 | 6.6 | 214.2 | 223 | 98 | 96 | 21 | 66 | 157 | 3 | 0 | 0 | 0 | 20 | 5 | 3 | 3.80 |
| SP | Dempster, R.Dempster, Ryan † >> | 31 | 2008 | R | 88 | 30 | 30 | 17 | 8 | 3.53 | .313 | 1.34 | 8.9 | 3.2 | 5.3 | 201.2 | 199 | 80 | 79 | 18 | 71 | 119 | 2 | 0 | 0 | 1 | 21 | 5 | 6 | 4.11 |
| SP | Guthrie, J.Guthrie, Jeremy >> | 29 | 2008 | R | 64 | 29 | 29 | 5 | 16 | 6.56 | .364 | 1.68 | 11.2 | 3.9 | 6.0 | 155.0 | 193 | 122 | 113 | 26 | 68 | 103 | 1 | 0 | 0 | 1 | 7 | 5 | 2 | 5.26 |
| SP | Greinke, Z.Greinke, Zack >> | 25 | 2008 | R | 53 | 28 | 28 | 7 | 12 | 5.46 | .348 | 1.57 | 11.8 | 2.4 | 6.8 | 163.1 | 213 | 103 | 99 | 25 | 44 | 124 | 1 | 0 | 0 | 0 | 12 | 4 | 7 | 4.36 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 98 | 97 | 0 | 4 | 4 | 2.75 | .275 | 1.13 | 5.5 | 4.6 | 8.7 | 95.0 | 58 | 33 | 29 | 10 | 49 | 92 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 4.01 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 84 | 96 | 0 | 2 | 4 | 2.36 | .278 | 1.08 | 6.6 | 3.2 | 9.5 | 91.2 | 67 | 25 | 24 | 4 | 32 | 96 | 0 | 4 | 2 | 0 | 0 | 7 | 1 | 2.75 |
| RP | Dotel, O.Dotel, Octavio † >> | 35 | 2008 | R | 69 | 92 | 0 | 3 | 4 | 1.59 | .270 | 1.10 | 7.0 | 2.9 | 9.7 | 90.1 | 70 | 22 | 16 | 5 | 29 | 97 | 0 | 14 | 5 | 0 | 0 | 1 | 2 | 2.57 |
| RP | Ramirez, E.Ramirez, Edwar >> | 27 | 2008 | R | 58 | 51 | 0 | 3 | 5 | 3.52 | .321 | 1.40 | 7.4 | 5.3 | 10.2 | 61.1 | 50 | 25 | 24 | 4 | 36 | 69 | 0 | 8 | 1 | 0 | 0 | 1 | 4 | 3.41 |