| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 99 | 5 | 5 | 0 | 3 | 6.85 | .349 | 1.61 | 11.7 | 3.1 | 7.8 | 23.2 | 30 | 18 | 18 | 5 | 8 | 20 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5.13 |
| SP | Beckett, J.Beckett, Josh >> | 28 | 2008 | R | 71 | 4 | 4 | 2 | 0 | 7.80 | .357 | 1.67 | 12.0 | 3.0 | 9.6 | 15.0 | 20 | 15 | 13 | 2 | 5 | 16 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 3.60 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 84 | 12 | 0 | 1 | 0 | 2.21 | .247 | 0.98 | 6.8 | 2.3 | 9.9 | 20.1 | 15 | 5 | 5 | 1 | 5 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.20 |
| RP | Wheeler, D.Wheeler, Dan >> | 31 | 2008 | R | 89 | 11 | 0 | 0 | 0 | 2.70 | .322 | 1.35 | 9.7 | 2.8 | 2.8 | 13.1 | 14 | 4 | 4 | 2 | 4 | 4 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 5.54 |
| RP | Broxton, J.Broxton, Jonathan >> | 24 | 2008 | R | 77 | 10 | 0 | 0 | 1 | 10.61 | .429 | 2.25 | 13.0 | 8.0 | 6.0 | 9.1 | 13 | 11 | 11 | 2 | 8 | 6 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 7.22 |
| RP | Saito, T.Saito, Takashi >> | 38 | 2008 | R | 63 | 4 | 0 | 0 | 0 | 0.00 | .313 | 1.36 | 12.0 | 3.0 | 12.0 | 3.2 | 4 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.33 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 28 | 2008 | R | 82 | 6 | 0 | 1 | 0 | 2.35 | .281 | 1.17 | 10.3 | 1.3 | 10.3 | 7.2 | 8 | 2 | 2 | 0 | 1 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.14 |