| SP | Halladay, R.Halladay, Roy >> | 31 | 2008 | R | 95 | 31 | 31 | 9 | 11 | 4.46 | .306 | 1.31 | 9.4 | 2.4 | 6.8 | 213.2 | 223 | 113 | 106 | 27 | 57 | 162 | 3 | 0 | 0 | 1 | 14 | 3 | 7 | 3.97 |
| SP | Kazmir, S.Kazmir, Scott † >> | 24 | 2008 | L | 80 | 30 | 30 | 15 | 6 | 3.12 | .307 | 1.31 | 7.1 | 4.8 | 9.9 | 158.2 | 124 | 65 | 55 | 12 | 84 | 173 | 0 | 0 | 0 | 0 | 9 | 3 | 1 | 3.45 |
| SP | Danks, J.Danks, John # >> | 23 | 2008 | L | 70 | 29 | 29 | 4 | 9 | 6.12 | .348 | 1.59 | 10.5 | 3.9 | 6.0 | 135.1 | 157 | 97 | 92 | 19 | 58 | 90 | 0 | 0 | 0 | 0 | 4 | 2 | 7 | 4.83 |
| SP | Wellemeyer, T.Wellemeyer, Todd # >> | 30 | 2008 | R | 61 | 28 | 28 | 8 | 6 | 5.65 | .328 | 1.44 | 10.2 | 2.7 | 6.3 | 138.2 | 157 | 90 | 87 | 24 | 42 | 96 | 0 | 0 | 0 | 0 | 8 | 4 | 5 | 4.87 |
| RP | Wagner, B.Wagner, Billy † >> | 37 | 2008 | L | 94 | 76 | 0 | 10 | 4 | 3.66 | .276 | 1.11 | 6.8 | 3.2 | 9.1 | 113.0 | 85 | 49 | 46 | 8 | 40 | 114 | 0 | 7 | 3 | 0 | 0 | 4 | 2 | 3.07 |
| RP | Francisco, F.Francisco, Frank >> | 29 | 2008 | R | 80 | 74 | 0 | 9 | 3 | 3.21 | .293 | 1.22 | 7.4 | 3.6 | 9.6 | 98.0 | 81 | 37 | 35 | 6 | 39 | 104 | 0 | 5 | 2 | 0 | 0 | 2 | 4 | 2.93 |
| RP | Marte, D.Marte, Damaso >> | 33 | 2008 | L | 64 | 61 | 0 | 9 | 5 | 3.77 | .287 | 1.19 | 7.2 | 3.6 | 9.1 | 76.1 | 61 | 37 | 32 | 9 | 30 | 77 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.74 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 26 | 2008 | R | 51 | 53 | 0 | 3 | 1 | 3.65 | .327 | 1.44 | 7.8 | 5.3 | 8.6 | 61.2 | 53 | 29 | 25 | 5 | 36 | 58 | 0 | 6 | 0 | 0 | 0 | 1 | 3 | 3.98 |