| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 99 | 38 | 38 | 15 | 12 | 3.73 | .300 | 1.25 | 8.4 | 2.9 | 6.2 | 236.1 | 221 | 100 | 98 | 19 | 75 | 162 | 0 | 0 | 0 | 0 | 25 | 8 | 6 | 3.73 |
| SP | Hudson, T.Hudson, Tim # >> | 33 | 2008 | R | 85 | 36 | 36 | 17 | 5 | 4.70 | .300 | 1.27 | 9.2 | 2.2 | 5.5 | 230.0 | 235 | 121 | 120 | 38 | 56 | 141 | 2 | 0 | 0 | 2 | 17 | 5 | 4 | 4.72 |
| SP | Wainwright, A.Wainwright, Adam # >> | 27 | 2008 | R | 75 | 34 | 34 | 13 | 10 | 5.54 | .338 | 1.48 | 10.4 | 2.9 | 5.7 | 200.0 | 232 | 124 | 123 | 32 | 64 | 126 | 2 | 0 | 0 | 1 | 12 | 11 | 5 | 4.95 |
| RP | Arredondo, J.Arredondo, Jose >> | 24 | 2008 | R | 85 | 105 | 0 | 10 | 4 | 3.03 | .281 | 1.15 | 6.6 | 3.9 | 6.4 | 133.2 | 97 | 46 | 45 | 7 | 57 | 95 | 0 | 9 | 8 | 0 | 0 | 3 | 3 | 3.61 |
| RP | Marte, D.Marte, Damaso >> | 33 | 2008 | L | 64 | 77 | 0 | 7 | 1 | 3.40 | .311 | 1.33 | 8.5 | 3.5 | 8.3 | 82.0 | 77 | 32 | 31 | 9 | 32 | 76 | 0 | 4 | 3 | 0 | 0 | 2 | 4 | 3.82 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 26 | 2008 | R | 51 | 41 | 0 | 4 | 2 | 6.07 | .337 | 1.46 | 8.4 | 4.7 | 8.4 | 46.0 | 43 | 31 | 31 | 5 | 24 | 43 | 0 | 2 | 2 | 0 | 0 | 3 | 3 | 4.30 |
| CL | Balfour, G.Balfour, Grant † >> | 31 | 2008 | R | 100 | 80 | 0 | 11 | 5 | 2.97 | .314 | 1.37 | 7.8 | 4.5 | 9.6 | 97.0 | 84 | 34 | 32 | 5 | 49 | 103 | 0 | 30 | 8 | 0 | 0 | 0 | 5 | 3.06 |