| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 100 | 3 | 3 | 1 | 1 | 6.61 | .364 | 1.71 | 11.8 | 3.9 | 7.3 | 16.1 | 21 | 12 | 12 | 0 | 7 | 13 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2.69 |
| SP | Volquez, E.Volquez, Edinson >> | 25 | 2008 | R | 66 | 3 | 3 | 2 | 0 | 2.12 | .282 | 1.18 | 5.8 | 4.8 | 9.5 | 17.0 | 11 | 4 | 4 | 1 | 9 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.24 |
| SP | Lackey, J.Lackey, John >> | 30 | 2008 | R | 58 | 3 | 3 | 1 | 1 | 4.58 | .352 | 1.63 | 14.2 | 0.9 | 6.6 | 19.2 | 30 | 10 | 10 | 2 | 2 | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.21 |
| SP | Maddux, G.Maddux, Greg >> | 42 | 2008 | R | 47 | 2 | 2 | 0 | 0 | 6.75 | .429 | 2.25 | 18.0 | 3.0 | 3.0 | 9.1 | 18 | 8 | 7 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.22 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 100 | 7 | 0 | 0 | 0 | 3.00 | .294 | 1.25 | 6.8 | 4.5 | 6.8 | 12.0 | 9 | 4 | 4 | 0 | 6 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Shell, S.Shell, Steven >> | 25 | 2008 | R | 84 | 9 | 0 | 1 | 2 | 8.10 | .348 | 1.60 | 7.2 | 7.2 | 9.0 | 10.0 | 8 | 9 | 9 | 3 | 8 | 10 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 7.30 |
| RP | Linebrink, S.Linebrink, Scott >> | 32 | 2008 | R | 65 | 8 | 0 | 1 | 1 | 2.31 | .271 | 1.11 | 6.5 | 4.1 | 4.9 | 11.2 | 8 | 3 | 3 | 2 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.64 |
| RP | Oliver, D.Oliver, Darren >> | 38 | 2008 | L | 50 | 8 | 0 | 0 | 0 | 4.50 | .333 | 1.25 | 9.0 | 2.3 | 7.9 | 8.0 | 8 | 4 | 4 | 2 | 2 | 7 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 6.00 |
| SP | Litsch, J.Litsch, Jesse >> | 23 | 2008 | R | 43 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Vazquez, J.Vazquez, Javier >> | 32 | 2008 | R | 40 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |