| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 100 | 31 | 31 | 14 | 9 | 4.15 | .313 | 1.33 | 9.0 | 3.0 | 7.0 | 203.2 | 204 | 99 | 94 | 26 | 67 | 158 | 1 | 0 | 0 | 0 | 16 | 7 | 0 | 4.20 |
| SP | Volquez, E.Volquez, Edinson >> | 25 | 2008 | R | 66 | 29 | 29 | 12 | 7 | 3.98 | .324 | 1.43 | 8.4 | 4.4 | 9.6 | 158.1 | 148 | 70 | 70 | 11 | 78 | 168 | 0 | 0 | 0 | 0 | 11 | 2 | 6 | 3.30 |
| SP | Lackey, J.Lackey, John # >> | 30 | 2008 | R | 58 | 29 | 29 | 9 | 12 | 4.82 | .317 | 1.38 | 9.9 | 2.6 | 7.0 | 188.2 | 206 | 106 | 101 | 29 | 55 | 147 | 2 | 0 | 0 | 1 | 14 | 2 | 2 | 4.35 |
| SP | Maddux, G.Maddux, Greg >> | 42 | 2008 | R | 47 | 28 | 28 | 7 | 10 | 5.88 | .329 | 1.45 | 10.7 | 2.4 | 5.6 | 145.1 | 173 | 98 | 95 | 23 | 38 | 90 | 0 | 0 | 0 | 0 | 11 | 3 | 4 | 4.67 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 100 | 76 | 0 | 6 | 3 | 2.85 | .273 | 1.10 | 6.0 | 4.0 | 8.3 | 123.1 | 82 | 42 | 39 | 6 | 54 | 114 | 0 | 2 | 5 | 0 | 0 | 3 | 2 | 3.17 |
| RP | Shell, S.Shell, Steven # >> | 25 | 2008 | R | 84 | 79 | 0 | 4 | 9 | 4.87 | .339 | 1.51 | 9.0 | 4.6 | 6.8 | 92.1 | 92 | 51 | 50 | 15 | 47 | 70 | 0 | 4 | 6 | 0 | 0 | 3 | 2 | 5.23 |
| RP | Linebrink, S.Linebrink, Scott >> | 32 | 2008 | R | 65 | 75 | 0 | 8 | 5 | 3.13 | .256 | 1.01 | 6.8 | 2.4 | 6.6 | 103.2 | 78 | 36 | 36 | 10 | 27 | 76 | 0 | 9 | 3 | 0 | 0 | 2 | 5 | 3.63 |
| RP | Oliver, D.Oliver, Darren >> | 38 | 2008 | L | 50 | 55 | 0 | 2 | 4 | 3.92 | .328 | 1.43 | 9.8 | 3.1 | 8.4 | 64.1 | 70 | 28 | 28 | 9 | 22 | 60 | 0 | 8 | 2 | 0 | 0 | 2 | 2 | 4.08 |
| SP | Litsch, J.Litsch, Jesse >> | 23 | 2008 | R | 43 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Vazquez, J.Vazquez, Javier >> | 32 | 2008 | R | 40 | 21 | 0 | 3 | 1 | 7.97 | .402 | 1.97 | 14.4 | 3.6 | 8.1 | 20.1 | 32 | 18 | 18 | 2 | 8 | 18 | 0 | 5 | 0 | 0 | 0 | 1 | 1 | 3.85 |