| SP | Sabathia, C.Sabathia, CC >> | 28 | 2008 | L | 98 | 24 | 24 | 11 | 8 | 4.00 | .317 | 1.36 | 10.1 | 2.3 | 6.5 | 168.2 | 188 | 77 | 75 | 13 | 42 | 122 | 5 | 0 | 0 | 1 | 15 | 5 | 2 | 3.39 |
| SP | Kazmir, S.Kazmir, Scott # >> | 24 | 2008 | L | 80 | 23 | 23 | 9 | 10 | 5.11 | .334 | 1.50 | 8.1 | 5.4 | 9.6 | 116.1 | 105 | 68 | 66 | 13 | 69 | 124 | 0 | 0 | 0 | 0 | 3 | 1 | 3 | 4.13 |
| SP | Wellemeyer, T.Wellemeyer, Todd >> | 30 | 2008 | R | 61 | 23 | 23 | 5 | 7 | 4.61 | .334 | 1.50 | 9.4 | 4.1 | 6.8 | 119.0 | 124 | 62 | 61 | 16 | 54 | 90 | 0 | 0 | 0 | 0 | 4 | 1 | 2 | 4.62 |
| SP | Maddux, G.Maddux, Greg # >> | 42 | 2008 | R | 47 | 22 | 22 | 7 | 9 | 5.19 | .347 | 1.58 | 11.5 | 2.7 | 5.6 | 118.0 | 151 | 73 | 68 | 14 | 35 | 74 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 4.23 |
| SP | Rodriguez, W.Rodriguez, Wandy >> | 29 | 2008 | L | 44 | 22 | 21 | 6 | 5 | 6.10 | .378 | 1.79 | 11.8 | 4.4 | 7.6 | 100.1 | 131 | 75 | 68 | 11 | 49 | 84 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 4.31 |
| RP | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 99 | 60 | 0 | 8 | 0 | 4.00 | .302 | 1.29 | 8.6 | 3.0 | 9.1 | 90.0 | 86 | 40 | 40 | 8 | 30 | 91 | 0 | 4 | 1 | 0 | 0 | 1 | 4 | 3.17 |
| RP | Shell, S.Shell, Steven >> | 25 | 2008 | R | 84 | 54 | 0 | 2 | 0 | 3.89 | .311 | 1.34 | 7.6 | 4.6 | 6.4 | 69.1 | 58 | 30 | 30 | 9 | 35 | 49 | 0 | 6 | 2 | 0 | 0 | 1 | 0 | 4.84 |
| RP | Linebrink, S.Linebrink, Scott >> | 32 | 2008 | R | 65 | 57 | 0 | 4 | 4 | 4.08 | .326 | 1.42 | 9.7 | 3.2 | 6.8 | 79.1 | 85 | 38 | 36 | 8 | 28 | 60 | 0 | 6 | 1 | 0 | 0 | 2 | 2 | 3.94 |
| RP | Romero, J.Romero, J.C. >> | 32 | 2008 | L | 49 | 49 | 0 | 6 | 4 | 3.48 | .315 | 1.34 | 7.9 | 4.2 | 6.6 | 67.1 | 59 | 26 | 26 | 6 | 31 | 49 | 0 | 5 | 3 | 0 | 0 | 3 | 3 | 4.22 |
| RP | Perez, C.Perez, Chris † >> | 23 | 2008 | R | 39 | 47 | 0 | 3 | 0 | 3.07 | .301 | 1.24 | 5.9 | 5.4 | 9.2 | 55.2 | 36 | 19 | 19 | 5 | 33 | 56 | 0 | 11 | 2 | 0 | 0 | 3 | 3 | 4.11 |
| SP | Hernandez, F.Hernandez, Felix >> | 22 | 2008 | R | 31 | 30 | 0 | 3 | 2 | 7.18 | .411 | 2.06 | 12.0 | 6.8 | 6.5 | 36.1 | 48 | 30 | 29 | 4 | 27 | 26 | 0 | 5 | 0 | 0 | 0 | 1 | 2 | 5.33 |