| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 100 | 22 | 22 | 4 | 11 | 4.56 | .319 | 1.40 | 9.1 | 3.5 | 6.2 | 130.1 | 131 | 68 | 66 | 18 | 51 | 89 | 1 | 0 | 0 | 0 | 11 | 1 | 0 | 4.63 |
| SP | Galarraga, A.Galarraga, Armando >> | 26 | 2008 | R | 81 | 23 | 23 | 4 | 10 | 4.52 | .301 | 1.26 | 8.3 | 3.1 | 5.9 | 123.1 | 114 | 67 | 62 | 15 | 42 | 80 | 0 | 0 | 0 | 0 | 9 | 3 | 4 | 4.38 |
| SP | Johnson, R.Johnson, Randy >> | 45 | 2008 | L | 60 | 22 | 22 | 5 | 9 | 4.98 | .346 | 1.58 | 11.1 | 3.1 | 7.0 | 119.1 | 147 | 77 | 66 | 18 | 41 | 93 | 0 | 0 | 0 | 0 | 11 | 1 | 2 | 4.46 |
| CL | Balfour, G.Balfour, Grant † >> | 31 | 2008 | R | 100 | 48 | 0 | 6 | 9 | 4.33 | .308 | 1.28 | 7.3 | 4.2 | 9.2 | 54.0 | 44 | 26 | 26 | 5 | 25 | 55 | 0 | 18 | 5 | 0 | 0 | 3 | 2 | 3.72 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 30 | 2008 | L | 67 | 81 | 0 | 4 | 0 | 2.74 | .245 | 0.94 | 5.5 | 3.0 | 8.7 | 69.0 | 42 | 21 | 21 | 5 | 23 | 67 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 3.09 |
| RP | Ramirez, R.Ramirez, Ramon >> | 27 | 2008 | R | 55 | 46 | 0 | 3 | 0 | 3.20 | .341 | 1.50 | 7.6 | 6.0 | 6.2 | 39.1 | 33 | 15 | 14 | 1 | 26 | 27 | 0 | 0 | 2 | 0 | 0 | 2 | 1 | 4.10 |
| RP | Tejeda, R.Tejeda, Robinson >> | 26 | 2008 | R | 86 | 35 | 0 | 4 | 0 | 4.38 | .302 | 1.30 | 7.3 | 4.4 | 10.0 | 37.0 | 30 | 18 | 18 | 4 | 18 | 41 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 3.65 |