| SP | Santana, J.Santana, Johan >> | 29 | 2008 | L | 93 | 3 | 3 | 1 | 0 | 2.08 | .235 | 0.78 | 6.4 | 0.9 | 7.7 | 21.2 | 15 | 5 | 5 | 0 | 2 | 18 | 0 | 0 | 0 | 0 | 3 | 3 | 0 | 2.00 |
| SP | Wakefield, T.Wakefield, Tim >> | 42 | 2008 | R | 83 | 3 | 3 | 0 | 1 | 4.11 | .324 | 1.43 | 9.6 | 3.6 | 6.0 | 15.1 | 16 | 7 | 7 | 1 | 6 | 10 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 3.73 |
| SP | Beckett, J.Beckett, Josh >> | 28 | 2008 | R | 71 | 3 | 3 | 1 | 0 | 1.69 | .238 | 0.89 | 6.4 | 1.7 | 6.0 | 21.1 | 15 | 4 | 4 | 2 | 4 | 14 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 3.62 |
| CL | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 92 | 6 | 0 | 2 | 0 | 1.29 | .192 | 0.71 | 2.6 | 3.9 | 10.3 | 7.0 | 2 | 1 | 1 | 0 | 3 | 8 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.00 |
| RP | Wheeler, D.Wheeler, Dan >> | 31 | 2008 | R | 89 | 7 | 0 | 0 | 0 | 2.35 | .303 | 1.30 | 7.7 | 5.1 | 9.0 | 7.2 | 6 | 2 | 2 | 2 | 4 | 7 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 6.43 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 28 | 2008 | R | 82 | 2 | 0 | 0 | 1 | 5.40 | .231 | 0.90 | 6.0 | 3.0 | 15.0 | 3.1 | 2 | 2 | 2 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.67 |
| RP | Broxton, J.Broxton, Jonathan >> | 24 | 2008 | R | 77 | 3 | 0 | 0 | 0 | 5.40 | .286 | 1.20 | 18.0 | 0.0 | 9.0 | 1.2 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.00 |
| SP | Weaver, J.Weaver, Jered >> | 26 | 2008 | R | 54 | 2 | 0 | 1 | 0 | 0.75 | .217 | 0.83 | 6.8 | 0.8 | 7.5 | 12.0 | 9 | 1 | 1 | 1 | 1 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.67 |