| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 96 | 25 | 25 | 10 | 8 | 3.57 | .285 | 1.19 | 8.4 | 2.4 | 6.3 | 158.2 | 147 | 69 | 63 | 14 | 42 | 110 | 2 | 0 | 0 | 0 | 15 | 1 | 1 | 3.58 |
| SP | Wakefield, T.Wakefield, Tim >> | 42 | 2008 | R | 83 | 24 | 24 | 7 | 8 | 4.08 | .304 | 1.30 | 8.6 | 3.1 | 5.7 | 139.0 | 133 | 66 | 63 | 15 | 48 | 88 | 0 | 0 | 0 | 0 | 14 | 1 | 11 | 4.19 |
| SP | Wainwright, A.Wainwright, Adam >> | 27 | 2008 | R | 75 | 25 | 24 | 10 | 9 | 3.77 | .301 | 1.26 | 9.0 | 2.4 | 6.0 | 148.0 | 148 | 63 | 62 | 13 | 39 | 98 | 0 | 0 | 0 | 0 | 18 | 4 | 3 | 3.69 |
| SP | Saunders, J.Saunders, Joe >> | 27 | 2008 | L | 65 | 23 | 23 | 9 | 8 | 4.59 | .298 | 1.25 | 8.7 | 2.6 | 5.5 | 135.1 | 130 | 70 | 69 | 18 | 39 | 83 | 0 | 0 | 0 | 0 | 12 | 3 | 3 | 4.44 |
| SP | Greinke, Z.Greinke, Zack >> | 25 | 2008 | R | 53 | 23 | 23 | 9 | 8 | 4.88 | .326 | 1.40 | 9.5 | 3.1 | 6.2 | 129.0 | 136 | 74 | 70 | 21 | 45 | 89 | 0 | 0 | 0 | 0 | 11 | 6 | 3 | 4.92 |
| CL | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 96 | 44 | 0 | 5 | 6 | 1.54 | .210 | 0.76 | 3.6 | 3.3 | 8.0 | 52.2 | 21 | 9 | 9 | 2 | 19 | 46 | 0 | 24 | 1 | 0 | 0 | 2 | 1 | 2.94 |
| RP | Tejeda, R.Tejeda, Robinson >> | 26 | 2008 | R | 86 | 67 | 0 | 4 | 3 | 4.08 | .334 | 1.49 | 6.9 | 6.7 | 8.2 | 81.2 | 62 | 40 | 37 | 5 | 60 | 74 | 0 | 0 | 4 | 0 | 0 | 1 | 9 | 4.23 |
| RP | Arredondo, J.Arredondo, Jose >> | 24 | 2008 | R | 85 | 62 | 0 | 2 | 3 | 3.25 | .294 | 1.22 | 7.4 | 3.6 | 7.6 | 72.0 | 59 | 27 | 26 | 8 | 29 | 61 | 0 | 3 | 1 | 0 | 0 | 2 | 2 | 4.04 |
| RP | Valverde, J.Valverde, Jose >> | 29 | 2008 | R | 66 | 28 | 0 | 2 | 0 | 4.91 | .318 | 1.36 | 10.6 | 1.9 | 9.3 | 29.1 | 34 | 17 | 16 | 6 | 6 | 30 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 4.34 |
| RP | Ziegler, B.Ziegler, Brad >> | 29 | 2008 | R | 59 | 24 | 0 | 0 | 0 | 4.50 | .328 | 1.40 | 9.3 | 3.3 | 5.7 | 30.0 | 31 | 15 | 15 | 6 | 11 | 19 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.63 |