| SP | Santana, J.Santana, Johan >> | 29 | 2008 | L | 93 | 31 | 31 | 12 | 8 | 3.18 | .283 | 1.16 | 8.2 | 2.3 | 7.3 | 198.1 | 181 | 71 | 70 | 16 | 50 | 160 | 2 | 0 | 0 | 1 | 21 | 4 | 3 | 3.25 |
| SP | Wakefield, T.Wakefield, Tim # >> | 42 | 2008 | R | 83 | 30 | 30 | 4 | 13 | 4.83 | .300 | 1.25 | 8.1 | 3.1 | 5.5 | 166.0 | 150 | 91 | 89 | 20 | 58 | 101 | 0 | 0 | 0 | 0 | 17 | 5 | 7 | 4.49 |
| SP | Beckett, J.Beckett, Josh >> | 28 | 2008 | R | 71 | 29 | 29 | 7 | 7 | 5.29 | .344 | 1.54 | 11.0 | 2.9 | 6.1 | 151.1 | 185 | 92 | 89 | 21 | 48 | 103 | 0 | 0 | 0 | 0 | 11 | 5 | 1 | 4.50 |
| SP | Floyd, G.Floyd, Gavin # >> | 25 | 2008 | R | 62 | 28 | 28 | 9 | 12 | 4.70 | .296 | 1.25 | 8.3 | 3.0 | 6.8 | 168.2 | 154 | 88 | 88 | 25 | 56 | 126 | 2 | 0 | 0 | 1 | 16 | 3 | 2 | 4.49 |
| CL | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 92 | 54 | 0 | 3 | 6 | 2.48 | .266 | 1.03 | 6.1 | 3.2 | 8.6 | 65.1 | 44 | 18 | 18 | 6 | 23 | 62 | 0 | 22 | 7 | 0 | 0 | 4 | 3 | 3.54 |
| RP | Wheeler, D.Wheeler, Dan >> | 31 | 2008 | R | 89 | 78 | 0 | 5 | 5 | 3.98 | .300 | 1.27 | 8.1 | 3.3 | 7.1 | 104.0 | 94 | 47 | 46 | 14 | 38 | 82 | 0 | 2 | 10 | 0 | 0 | 2 | 1 | 4.33 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 28 | 2008 | R | 82 | 35 | 0 | 2 | 2 | 3.14 | .283 | 1.16 | 8.0 | 2.5 | 9.6 | 43.0 | 38 | 17 | 15 | 4 | 12 | 46 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 2.98 |
| RP | Broxton, J.Broxton, Jonathan >> | 24 | 2008 | R | 77 | 27 | 0 | 5 | 3 | 6.85 | .366 | 1.73 | 10.6 | 5.5 | 11.0 | 23.2 | 27 | 18 | 18 | 2 | 14 | 28 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.52 |
| SP | Weaver, J.Weaver, Jered >> | 26 | 2008 | R | 54 | 17 | 0 | 1 | 2 | 3.00 | .287 | 1.19 | 8.3 | 2.5 | 6.4 | 72.0 | 66 | 24 | 24 | 8 | 20 | 51 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 3.90 |