| SP | Sabathia, C.Sabathia, CC † >> | 28 | 2008 | L | 98 | 36 | 36 | 13 | 16 | 3.97 | .300 | 1.24 | 8.4 | 2.8 | 7.9 | 231.1 | 215 | 107 | 102 | 20 | 71 | 203 | 5 | 0 | 0 | 2 | 21 | 11 | 4 | 3.43 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 88 | 35 | 35 | 13 | 13 | 4.32 | .343 | 1.53 | 9.4 | 4.5 | 6.3 | 191.2 | 199 | 98 | 92 | 14 | 95 | 133 | 0 | 0 | 0 | 0 | 18 | 6 | 5 | 4.15 |
| SP | Guthrie, J.Guthrie, Jeremy >> | 29 | 2008 | R | 64 | 33 | 32 | 9 | 9 | 5.50 | .326 | 1.44 | 10.0 | 3.0 | 6.8 | 173.1 | 192 | 106 | 106 | 23 | 57 | 131 | 0 | 0 | 0 | 0 | 15 | 2 | 6 | 4.24 |
| CL | Marmol, C.Marmol, Carlos † >> | 26 | 2008 | R | 98 | 76 | 0 | 5 | 5 | 3.44 | .312 | 1.32 | 6.2 | 5.7 | 9.1 | 81.0 | 56 | 31 | 31 | 3 | 51 | 82 | 0 | 42 | 2 | 0 | 0 | 3 | 0 | 3.46 |
| RP | Wheeler, D.Wheeler, Dan >> | 31 | 2008 | R | 89 | 102 | 0 | 2 | 5 | 4.07 | .315 | 1.35 | 7.7 | 4.5 | 7.1 | 121.2 | 104 | 56 | 55 | 18 | 60 | 95 | 0 | 4 | 6 | 0 | 0 | 4 | 2 | 4.95 |
| RP | Broxton, J.Broxton, Jonathan >> | 24 | 2008 | R | 77 | 72 | 0 | 5 | 6 | 4.69 | .306 | 1.28 | 8.4 | 3.2 | 8.4 | 78.2 | 73 | 41 | 41 | 8 | 28 | 73 | 0 | 2 | 3 | 0 | 0 | 3 | 7 | 3.65 |
| RP | Dotel, O.Dotel, Octavio # >> | 35 | 2008 | R | 69 | 41 | 0 | 4 | 2 | 6.96 | .379 | 1.83 | 10.1 | 6.6 | 6.6 | 42.2 | 47 | 33 | 33 | 9 | 31 | 31 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 6.52 |
| RP | Reyes, D.Reyes, Dennys >> | 31 | 2008 | L | 53 | 113 | 0 | 6 | 4 | 3.76 | .283 | 1.18 | 7.0 | 3.7 | 7.7 | 103.0 | 80 | 47 | 43 | 12 | 42 | 88 | 0 | 2 | 3 | 0 | 0 | 0 | 4 | 4.03 |