| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 99 | 3 | 3 | 2 | 0 | 2.75 | .280 | 1.17 | 9.0 | 1.9 | 6.2 | 19.2 | 19 | 6 | 6 | 1 | 4 | 13 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2.95 |
| SP | Wainwright, A.Wainwright, Adam >> | 27 | 2008 | R | 75 | 3 | 3 | 1 | 1 | 10.80 | .403 | 1.95 | 14.5 | 3.5 | 6.9 | 13.1 | 21 | 16 | 16 | 8 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 10.85 |
| CL | Devine, J.Devine, Joey >> | 25 | 2008 | R | 100 | 7 | 0 | 1 | 0 | 0.00 | .313 | 1.36 | 5.1 | 7.7 | 12.9 | 7.1 | 4 | 0 | 0 | 0 | 6 | 10 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 2.71 |
| SU | Arredondo, J.Arredondo, Jose >> | 24 | 2008 | R | 85 | 8 | 0 | 0 | 0 | 4.35 | .367 | 1.74 | 4.5 | 11.7 | 6.3 | 10.1 | 5 | 5 | 5 | 0 | 13 | 7 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.50 |
| RP | Masterson, J.Masterson, Justin >> | 23 | 2008 | R | 57 | 7 | 0 | 2 | 0 | 2.35 | .378 | 1.43 | 12.9 | 1.3 | 2.6 | 7.2 | 10 | 2 | 2 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 6.00 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 30 | 2008 | L | 67 | 9 | 0 | 1 | 0 | 2.45 | .353 | 1.50 | 6.4 | 7.7 | 12.9 | 7.1 | 5 | 2 | 2 | 0 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.14 |
| RP | Romero, J.Romero, J.C. >> | 32 | 2008 | L | 49 | 5 | 0 | 0 | 0 | 3.38 | .273 | 1.13 | 5.4 | 5.4 | 12.6 | 5.1 | 3 | 2 | 2 | 1 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.60 |
| RP | Qualls, C.Qualls, Chad >> | 30 | 2008 | R | 76 | 7 | 0 | 0 | 0 | 7.36 | .389 | 1.91 | 12.9 | 5.1 | 7.7 | 7.1 | 10 | 6 | 6 | 2 | 4 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 6.71 |
| SP | Padilla, V.Padilla, Vicente >> | 31 | 2008 | R | 9 | 4 | 2 | 0 | 1 | 6.32 | .373 | 1.60 | 10.8 | 4.2 | 7.8 | 15.2 | 18 | 11 | 11 | 4 | 7 | 13 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 6.73 |