| SP | Marcum, S.Marcum, Shaun >> | 27 | 2008 | R | 92 | 38 | 38 | 19 | 8 | 3.57 | .320 | 1.39 | 9.0 | 3.5 | 7.1 | 242.1 | 242 | 103 | 96 | 26 | 95 | 191 | 1 | 0 | 0 | 0 | 23 | 5 | 4 | 4.06 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 27 | 2008 | R | 57 | 35 | 35 | 12 | 11 | 5.88 | .340 | 1.52 | 9.9 | 3.8 | 6.5 | 202.0 | 222 | 139 | 132 | 37 | 85 | 145 | 1 | 0 | 0 | 0 | 10 | 5 | 5 | 5.28 |
| RP | Devine, J.Devine, Joey † >> | 25 | 2008 | R | 100 | 105 | 0 | 8 | 7 | 2.71 | .278 | 1.14 | 6.2 | 4.1 | 9.9 | 146.1 | 101 | 53 | 44 | 10 | 66 | 161 | 0 | 5 | 4 | 0 | 0 | 2 | 0 | 3.08 |
| RP | Francisco, F.Francisco, Frank >> | 29 | 2008 | R | 80 | 103 | 0 | 6 | 6 | 4.49 | .360 | 1.67 | 8.7 | 6.4 | 9.9 | 116.1 | 112 | 65 | 58 | 16 | 82 | 128 | 0 | 8 | 4 | 0 | 0 | 2 | 3 | 4.76 |
| RP | Qualls, C.Qualls, Chad >> | 30 | 2008 | R | 76 | 80 | 0 | 5 | 9 | 3.00 | .312 | 1.34 | 9.6 | 2.5 | 5.6 | 102.0 | 109 | 37 | 34 | 5 | 28 | 63 | 0 | 8 | 1 | 0 | 0 | 2 | 5 | 3.28 |
| RP | Linebrink, S.Linebrink, Scott >> | 32 | 2008 | R | 65 | 66 | 0 | 5 | 2 | 2.89 | .247 | 0.95 | 6.4 | 2.2 | 8.4 | 90.1 | 64 | 31 | 29 | 12 | 22 | 84 | 0 | 8 | 1 | 0 | 0 | 3 | 3 | 3.70 |
| SP | Arroyo, B.Arroyo, Bronson >> | 31 | 2008 | R | 14 | 33 | 31 | 8 | 13 | 6.49 | .363 | 1.67 | 11.5 | 3.5 | 6.3 | 155.1 | 198 | 114 | 112 | 25 | 61 | 109 | 0 | 0 | 0 | 0 | 4 | 6 | 5 | 4.99 |