| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 96 | 5 | 5 | 0 | 2 | 3.60 | .271 | 1.09 | 8.0 | 1.8 | 6.4 | 35.0 | 31 | 14 | 14 | 2 | 7 | 25 | 1 | 0 | 0 | 0 | 3 | 1 | 1 | 3.00 |
| SP | Wakefield, T.Wakefield, Tim >> | 42 | 2008 | R | 83 | 4 | 4 | 2 | 1 | 3.65 | .321 | 1.30 | 9.4 | 2.6 | 7.9 | 24.2 | 25 | 11 | 10 | 1 | 7 | 21 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 3.04 |
| SP | Galarraga, A.Galarraga, Armando >> | 26 | 2008 | R | 81 | 3 | 3 | 1 | 1 | 1.83 | .203 | 0.76 | 5.7 | 1.4 | 4.3 | 19.2 | 12 | 4 | 4 | 1 | 3 | 9 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 3.21 |
| SP | Johnson, R.Johnson, Randy >> | 45 | 2008 | L | 60 | 4 | 4 | 1 | 3 | 5.48 | .330 | 1.30 | 9.4 | 2.3 | 5.5 | 23.0 | 24 | 14 | 14 | 3 | 6 | 14 | 0 | 0 | 0 | 0 | 2 | 4 | 0 | 4.78 |
| SP | Lackey, J.Lackey, John >> | 30 | 2008 | R | 58 | 4 | 4 | 0 | 3 | 8.20 | .411 | 2.04 | 13.5 | 5.5 | 7.0 | 18.2 | 27 | 19 | 17 | 2 | 11 | 14 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4.89 |
| RP | Tejeda, R.Tejeda, Robinson >> | 26 | 2008 | R | 86 | 9 | 0 | 0 | 0 | 3.38 | .347 | 1.59 | 8.1 | 7.2 | 4.5 | 10.2 | 9 | 5 | 4 | 0 | 8 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.40 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 26 | 2008 | R | 81 | 8 | 0 | 1 | 0 | 8.31 | .447 | 2.42 | 15.8 | 7.9 | 7.9 | 8.2 | 14 | 9 | 8 | 1 | 7 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.50 |
| RP | Linebrink, S.Linebrink, Scott >> | 32 | 2008 | R | 65 | 6 | 0 | 0 | 0 | 18.00 | .483 | 2.60 | 19.8 | 3.6 | 3.6 | 5.0 | 11 | 10 | 10 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 9.20 |
| RP | Oliver, D.Oliver, Darren >> | 38 | 2008 | L | 50 | 7 | 0 | 0 | 0 | 3.00 | .206 | 0.78 | 5.0 | 2.0 | 3.0 | 9.0 | 5 | 3 | 3 | 1 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.44 |
| SU | Hoffman, T.Hoffman, Trevor >> | 41 | 2008 | R | 78 | 6 | 0 | 1 | 1 | 13.50 | .484 | 2.63 | 23.4 | 1.8 | 7.2 | 5.1 | 13 | 8 | 8 | 3 | 1 | 4 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 10.40 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 99 | 6 | 0 | 2 | 0 | 2.45 | .185 | 0.68 | 6.4 | 0.0 | 15.4 | 7.1 | 5 | 2 | 2 | 2 | 0 | 12 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.29 |