| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 99 | 31 | 31 | 14 | 11 | 3.90 | .307 | 1.29 | 8.8 | 2.9 | 6.6 | 187.0 | 182 | 84 | 81 | 20 | 60 | 137 | 0 | 0 | 0 | 0 | 20 | 6 | 4 | 3.98 |
| SP | Wainwright, A.Wainwright, Adam >> | 27 | 2008 | R | 75 | 29 | 29 | 5 | 15 | 7.54 | .369 | 1.71 | 12.2 | 3.2 | 5.7 | 151.2 | 205 | 134 | 127 | 29 | 54 | 96 | 0 | 0 | 0 | 0 | 8 | 7 | 3 | 5.44 |
| CL | Devine, J.Devine, Joey † >> | 25 | 2008 | R | 100 | 61 | 0 | 4 | 3 | 1.84 | .279 | 1.16 | 6.5 | 4.0 | 9.6 | 58.2 | 42 | 13 | 12 | 2 | 26 | 62 | 0 | 33 | 2 | 0 | 0 | 0 | 0 | 2.66 |
| SU | Arredondo, J.Arredondo, Jose >> | 24 | 2008 | R | 85 | 62 | 0 | 4 | 4 | 4.48 | .326 | 1.36 | 7.3 | 5.0 | 6.9 | 68.1 | 55 | 35 | 34 | 3 | 38 | 52 | 0 | 4 | 6 | 0 | 0 | 6 | 0 | 3.99 |
| RP | Masterson, J.Masterson, Justin >> | 23 | 2008 | R | 57 | 82 | 0 | 7 | 1 | 4.38 | .327 | 1.42 | 8.5 | 4.2 | 5.9 | 115.0 | 109 | 60 | 56 | 14 | 54 | 76 | 0 | 0 | 2 | 0 | 0 | 5 | 1 | 4.80 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 30 | 2008 | L | 67 | 89 | 0 | 4 | 1 | 2.70 | .302 | 1.21 | 6.7 | 4.2 | 9.9 | 70.0 | 52 | 25 | 21 | 4 | 33 | 77 | 0 | 0 | 4 | 0 | 0 | 6 | 0 | 3.21 |
| RP | Romero, J.Romero, J.C. >> | 32 | 2008 | L | 49 | 74 | 0 | 2 | 3 | 3.34 | .309 | 1.32 | 7.6 | 4.5 | 8.5 | 56.2 | 47 | 21 | 21 | 5 | 28 | 53 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.82 |
| RP | Qualls, C.Qualls, Chad >> | 30 | 2008 | R | 76 | 66 | 0 | 5 | 3 | 4.03 | .315 | 1.34 | 8.4 | 3.7 | 7.1 | 76.0 | 71 | 34 | 34 | 9 | 31 | 60 | 0 | 1 | 2 | 0 | 0 | 3 | 2 | 4.30 |
| SP | Padilla, V.Padilla, Vicente >> | 31 | 2008 | R | 9 | 30 | 27 | 5 | 11 | 8.28 | .407 | 1.98 | 13.7 | 4.2 | 5.3 | 125.0 | 190 | 117 | 115 | 25 | 58 | 74 | 0 | 0 | 0 | 0 | 4 | 9 | 10 | 6.02 |