| SP | Peavy, J.Peavy, Jake † >> | 27 | 2008 | R | 91 | 31 | 31 | 15 | 5 | 3.78 | .292 | 1.23 | 8.0 | 3.1 | 6.4 | 188.0 | 168 | 80 | 79 | 17 | 64 | 133 | 1 | 0 | 0 | 1 | 20 | 1 | 2 | 3.80 |
| SP | Galarraga, A.Galarraga, Armando >> | 26 | 2008 | R | 81 | 29 | 29 | 14 | 7 | 4.64 | .323 | 1.42 | 9.1 | 3.7 | 6.4 | 151.1 | 153 | 78 | 78 | 22 | 62 | 108 | 0 | 0 | 0 | 0 | 13 | 2 | 4 | 4.74 |
| SP | Burnett, A.Burnett, A.J. >> | 31 | 2008 | R | 49 | 29 | 29 | 13 | 7 | 4.55 | .327 | 1.43 | 9.1 | 3.7 | 8.6 | 174.0 | 176 | 91 | 88 | 19 | 72 | 166 | 1 | 0 | 0 | 0 | 15 | 6 | 9 | 3.86 |
| SP | Johnson, R.Johnson, Randy # >> | 45 | 2008 | L | 60 | 27 | 27 | 10 | 13 | 4.46 | .298 | 1.25 | 8.6 | 2.7 | 8.1 | 171.1 | 163 | 86 | 85 | 25 | 52 | 153 | 0 | 0 | 0 | 0 | 13 | 3 | 4 | 4.08 |
| RP | Tejeda, R.Tejeda, Robinson >> | 26 | 2008 | R | 86 | 77 | 0 | 11 | 4 | 2.73 | .277 | 1.12 | 5.3 | 4.8 | 8.8 | 105.1 | 62 | 36 | 32 | 5 | 56 | 103 | 0 | 8 | 7 | 0 | 0 | 3 | 7 | 3.34 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 83 | 68 | 0 | 6 | 4 | 3.22 | .308 | 1.31 | 7.9 | 4.0 | 9.5 | 72.2 | 63 | 34 | 26 | 6 | 32 | 76 | 0 | 12 | 4 | 0 | 0 | 2 | 3 | 3.39 |
| RP | Saito, T.Saito, Takashi >> | 38 | 2008 | R | 63 | 36 | 0 | 1 | 1 | 0.93 | .227 | 0.85 | 4.7 | 3.1 | 10.4 | 38.2 | 20 | 4 | 4 | 2 | 13 | 44 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 2.47 |
| RP | Grabow, J.Grabow, John >> | 30 | 2008 | L | 46 | 35 | 0 | 3 | 0 | 3.92 | .303 | 1.26 | 6.9 | 4.6 | 8.4 | 43.2 | 33 | 19 | 19 | 4 | 22 | 40 | 0 | 2 | 0 | 0 | 0 | 2 | 3 | 4.02 |