| SP | Peavy, J.Peavy, Jake # >> | 27 | 2008 | R | 91 | 37 | 37 | 17 | 10 | 3.31 | .288 | 1.18 | 7.5 | 3.1 | 7.6 | 228.1 | 191 | 90 | 84 | 23 | 79 | 193 | 1 | 0 | 0 | 1 | 20 | 7 | 8 | 3.75 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 80 | 36 | 34 | 11 | 9 | 3.73 | .317 | 1.35 | 8.1 | 4.1 | 9.1 | 186.0 | 168 | 79 | 77 | 21 | 84 | 189 | 0 | 0 | 0 | 0 | 13 | 7 | 3 | 3.90 |
| SP | Beckett, J.Beckett, Josh # >> | 28 | 2008 | R | 71 | 34 | 34 | 14 | 12 | 4.65 | .323 | 1.40 | 10.6 | 2.0 | 7.5 | 203.1 | 240 | 112 | 105 | 25 | 45 | 170 | 1 | 0 | 0 | 0 | 18 | 6 | 2 | 3.68 |
| RP | Buchholz, T.Buchholz, Taylor >> | 27 | 2008 | R | 91 | 90 | 0 | 2 | 6 | 3.30 | .279 | 1.13 | 7.7 | 2.6 | 5.9 | 114.2 | 97 | 47 | 42 | 13 | 33 | 75 | 0 | 6 | 4 | 0 | 0 | 3 | 9 | 4.11 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 84 | 93 | 0 | 5 | 5 | 3.38 | .309 | 1.32 | 8.3 | 3.6 | 10.0 | 125.1 | 115 | 53 | 47 | 15 | 50 | 139 | 0 | 7 | 6 | 0 | 0 | 3 | 4 | 3.61 |
| RP | Percival, T.Percival, Troy >> | 39 | 2008 | R | 61 | 64 | 0 | 8 | 5 | 4.24 | .332 | 1.43 | 7.8 | 5.1 | 7.2 | 76.1 | 66 | 39 | 36 | 6 | 43 | 61 | 0 | 7 | 5 | 0 | 0 | 5 | 4 | 4.32 |
| RP | Masterson, J.Masterson, Justin >> | 23 | 2008 | R | 57 | 51 | 0 | 2 | 1 | 2.89 | .337 | 1.50 | 7.9 | 5.7 | 6.8 | 74.2 | 65 | 29 | 24 | 9 | 47 | 56 | 0 | 5 | 2 | 0 | 0 | 2 | 1 | 5.05 |
| SP | Burnett, A.Burnett, A.J. >> | 31 | 2008 | R | 49 | 12 | 0 | 4 | 2 | 3.72 | .376 | 1.81 | 10.9 | 5.7 | 8.1 | 19.1 | 23 | 8 | 8 | 2 | 12 | 17 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.47 |