| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 8 | 2 | 1 | 1 | 5.23 | .336 | 1.52 | 9.0 | 4.6 | 7.5 | 31.0 | 31 | 18 | 18 | 2 | 16 | 26 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 3.71 |
| SP | Hunter, C.Hunter, Catfish † # >> | 26 | 1972 | R | 81 | 18 | 18 | 12 | 2 | 3.23 | .251 | 0.97 | 7.1 | 1.7 | 5.0 | 136.1 | 107 | 49 | 49 | 14 | 25 | 76 | 2 | 0 | 0 | 0 | 14 | 5 | 1 | 3.88 |
| SP | Verlander, J.Verlander, Justin † $$ >> | 36 | 2019 | R | 99 | 18 | 18 | 10 | 4 | 2.85 | .255 | 1.01 | 6.8 | 2.3 | 9.3 | 142.0 | 108 | 48 | 45 | 12 | 36 | 147 | 6 | 0 | 0 | 0 | 15 | 2 | 0 | 2.83 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 17 | 17 | 5 | 9 | 4.93 | .295 | 1.24 | 8.4 | 2.8 | 6.1 | 107.2 | 100 | 60 | 59 | 8 | 33 | 72 | 0 | 0 | 0 | 0 | 8 | 2 | 2 | 3.61 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 36 | 0 | 0 | 0 | 1.49 | .216 | 0.77 | 5.0 | 2.0 | 9.5 | 36.1 | 20 | 6 | 6 | 2 | 8 | 38 | 0 | 32 | 2 | 0 | 0 | 2 | 0 | 2.44 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 41 | 0 | 2 | 3 | 3.56 | .336 | 1.48 | 7.2 | 6.3 | 9.0 | 30.1 | 24 | 13 | 12 | 2 | 21 | 30 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.07 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 12 | 0 | 1 | 1 | 4.76 | .292 | 1.24 | 7.4 | 4.1 | 7.4 | 11.1 | 9 | 6 | 6 | 2 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.09 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 3 | 0 | 0 | 0 | 4.91 | .353 | 1.64 | 6.0 | 12.0 | 12.0 | 3.2 | 2 | 2 | 2 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.33 |