| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 11 | 5 | 3.48 | .278 | 1.14 | 8.1 | 2.1 | 9.4 | 168.0 | 152 | 71 | 65 | 21 | 40 | 176 | 0 | 0 | 0 | 0 | 17 | 2 | 0 | 3.28 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 25 | 25 | 14 | 8 | 3.85 | .275 | 1.13 | 7.8 | 2.4 | 5.9 | 175.1 | 151 | 86 | 75 | 22 | 47 | 115 | 4 | 0 | 0 | 1 | 16 | 2 | 2 | 4.16 |
| SP | Gibson, B.Gibson, Bob † >> | 33 | 1968 | R | 93 | 25 | 25 | 15 | 7 | 2.91 | .271 | 1.09 | 7.0 | 2.8 | 5.7 | 204.1 | 159 | 73 | 66 | 17 | 63 | 129 | 15 | 0 | 0 | 3 | 17 | 6 | 4 | 3.83 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 24 | 24 | 13 | 7 | 4.71 | .297 | 1.21 | 8.2 | 2.7 | 7.3 | 141.1 | 129 | 77 | 74 | 18 | 42 | 115 | 0 | 0 | 0 | 0 | 11 | 8 | 3 | 4.09 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 66 | 0 | 4 | 4 | 3.48 | .271 | 1.09 | 7.6 | 2.3 | 8.1 | 88.0 | 74 | 37 | 34 | 13 | 22 | 79 | 0 | 12 | 4 | 0 | 0 | 2 | 1 | 3.94 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 49 | 0 | 4 | 2 | 3.81 | .275 | 1.12 | 8.7 | 1.4 | 8.7 | 59.0 | 57 | 27 | 25 | 9 | 9 | 57 | 0 | 11 | 2 | 0 | 0 | 1 | 0 | 3.56 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 36 | 0 | 4 | 0 | 0.84 | .237 | 0.88 | 4.8 | 3.1 | 10.5 | 43.0 | 23 | 4 | 4 | 2 | 15 | 50 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 2.47 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 22 | 0 | 2 | 1 | 2.60 | .278 | 1.16 | 8.3 | 2.3 | 8.0 | 27.2 | 25 | 9 | 8 | 2 | 7 | 24 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 2.96 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 21 | 0 | 2 | 1 | 4.71 | .250 | 1.00 | 7.7 | 1.3 | 10.3 | 21.0 | 18 | 11 | 11 | 4 | 3 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.62 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 20 | 0 | 1 | 0 | 3.42 | .324 | 1.44 | 9.0 | 4.3 | 8.2 | 23.2 | 23 | 9 | 9 | 2 | 11 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.74 |