| SP | Scherzer, M.Scherzer, Max >> | 34 | 2018 | R | 100 | 36 | 36 | 15 | 12 | 3.59 | .288 | 1.19 | 7.6 | 3.1 | 10.8 | 233.0 | 198 | 93 | 93 | 20 | 80 | 280 | 2 | 0 | 0 | 1 | 23 | 5 | 3 | 2.81 |
| SP | Paxton, J.Paxton, James >> | 29 | 2018 | L | 89 | 35 | 35 | 15 | 11 | 4.19 | .311 | 1.33 | 9.2 | 2.7 | 9.9 | 189.0 | 194 | 90 | 88 | 18 | 57 | 208 | 0 | 0 | 0 | 0 | 21 | 5 | 12 | 3.02 |
| SP | Greinke, Z.Greinke, Zack # >> | 35 | 2018 | R | 84 | 33 | 33 | 14 | 14 | 4.32 | .305 | 1.25 | 8.8 | 2.5 | 9.7 | 195.2 | 190 | 94 | 94 | 28 | 55 | 211 | 0 | 0 | 0 | 0 | 20 | 13 | 1 | 3.75 |
| SP | Kluber, C.Kluber, Corey >> | 32 | 2018 | R | 91 | 34 | 33 | 14 | 14 | 4.27 | .315 | 1.34 | 9.4 | 2.7 | 9.7 | 204.2 | 213 | 101 | 97 | 25 | 62 | 220 | 0 | 0 | 0 | 0 | 18 | 8 | 1 | 3.47 |
| CL | McHugh, C.McHugh, Collin † >> | 31 | 2018 | R | 96 | 69 | 0 | 4 | 6 | 2.59 | .265 | 1.04 | 6.4 | 3.0 | 10.2 | 73.0 | 52 | 21 | 21 | 8 | 24 | 83 | 0 | 49 | 2 | 0 | 0 | 3 | 0 | 3.26 |
| RP | Jeffress, J.Jeffress, Jeremy >> | 30 | 2018 | R | 91 | 93 | 0 | 5 | 2 | 2.88 | .312 | 1.33 | 8.1 | 3.9 | 9.3 | 112.2 | 101 | 40 | 36 | 9 | 49 | 116 | 0 | 4 | 3 | 0 | 0 | 3 | 0 | 3.37 |
| RP | Fields, J.Fields, Josh >> | 32 | 2018 | R | 87 | 79 | 0 | 4 | 4 | 2.75 | .275 | 1.09 | 7.2 | 2.7 | 7.5 | 95.0 | 76 | 32 | 29 | 11 | 28 | 79 | 0 | 2 | 1 | 0 | 0 | 4 | 0 | 3.85 |
| RP | Jansen, K.Jansen, Kenley >> | 30 | 2018 | R | 85 | 55 | 0 | 5 | 1 | 2.24 | .232 | 0.88 | 5.3 | 2.6 | 9.8 | 68.1 | 40 | 18 | 17 | 4 | 20 | 74 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 2.56 |
| RP | Rodriguez, R.Rodriguez, Richard >> | 28 | 2018 | R | 77 | 34 | 0 | 2 | 1 | 4.54 | .324 | 1.41 | 9.5 | 3.5 | 10.2 | 39.2 | 41 | 20 | 20 | 9 | 15 | 44 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 4.97 |
| RP | Hughes, J.Hughes, Jared >> | 32 | 2018 | R | 76 | 24 | 0 | 1 | 0 | 5.95 | .385 | 1.88 | 12.3 | 5.2 | 7.1 | 19.2 | 26 | 13 | 13 | 2 | 11 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.53 |
| RP | Hirano, Y.Hirano, Yoshihisa >> | 34 | 2018 | R | 70 | 25 | 0 | 1 | 0 | 3.23 | .338 | 1.50 | 9.6 | 4.2 | 7.8 | 30.2 | 32 | 11 | 11 | 2 | 14 | 26 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.63 |
| SP | Wacha, M.Wacha, Michael # >> | 26 | 2018 | R | 70 | 16 | 1 | 4 | 1 | 5.57 | .333 | 1.48 | 9.6 | 3.9 | 9.3 | 64.2 | 68 | 42 | 40 | 9 | 28 | 66 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.13 |
| SP | Rodriguez, D.Rodriguez, Dereck >> | 26 | 2018 | R | 76 | 31 | 31 | 9 | 10 | 5.39 | .335 | 1.46 | 9.6 | 3.5 | 6.7 | 150.1 | 160 | 95 | 90 | 24 | 59 | 112 | 0 | 0 | 0 | 0 | 12 | 8 | 1 | 4.93 |