| SP | Paxton, J.Paxton, James >> | 29 | 2018 | L | 89 | 20 | 20 | 5 | 8 | 5.82 | .353 | 1.58 | 10.2 | 4.0 | 10.9 | 102.0 | 116 | 68 | 66 | 15 | 45 | 123 | 0 | 0 | 0 | 0 | 7 | 6 | 6 | 4.00 |
| SP | Greinke, Z.Greinke, Zack # >> | 35 | 2018 | R | 84 | 20 | 20 | 10 | 6 | 4.92 | .331 | 1.42 | 9.7 | 3.1 | 7.8 | 104.1 | 112 | 57 | 57 | 16 | 36 | 90 | 0 | 0 | 0 | 0 | 10 | 7 | 3 | 4.51 |
| SP | Chacin, J.Chacin, Jhoulys >> | 30 | 2018 | R | 78 | 20 | 19 | 6 | 4 | 4.27 | .320 | 1.39 | 8.1 | 4.5 | 7.9 | 97.0 | 87 | 48 | 46 | 9 | 48 | 85 | 0 | 0 | 0 | 0 | 7 | 2 | 4 | 4.00 |
| CL | Leclerc, J.Leclerc, Jose † >> | 24 | 2018 | R | 99 | 43 | 0 | 5 | 3 | 3.42 | .275 | 1.12 | 6.1 | 4.0 | 10.3 | 50.0 | 34 | 19 | 19 | 4 | 22 | 57 | 0 | 21 | 1 | 0 | 0 | 1 | 4 | 3.14 |
| RP | Jeffress, J.Jeffress, Jeremy >> | 30 | 2018 | R | 91 | 53 | 0 | 7 | 4 | 4.57 | .310 | 1.30 | 7.1 | 4.6 | 9.0 | 63.0 | 50 | 33 | 32 | 5 | 32 | 63 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 3.70 |
| RP | Moronta, R.Moronta, Reyes >> | 25 | 2018 | R | 84 | 44 | 0 | 1 | 1 | 3.66 | .300 | 1.26 | 6.7 | 4.9 | 10.0 | 46.2 | 34 | 19 | 19 | 5 | 25 | 51 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 3.89 |
| RP | Miller, J.Miller, Justin >> | 31 | 2018 | R | 67 | 42 | 0 | 2 | 0 | 3.02 | .286 | 1.18 | 8.1 | 2.6 | 11.0 | 41.2 | 37 | 15 | 14 | 5 | 12 | 50 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 3.10 |
| SP | Wacha, M.Wacha, Michael >> | 26 | 2018 | R | 70 | 20 | 0 | 2 | 1 | 4.61 | .328 | 1.46 | 10.4 | 2.9 | 6.2 | 52.2 | 60 | 28 | 27 | 7 | 17 | 36 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 4.35 |