| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 13 | 13 | 4 | 4 | 5.29 | .341 | 1.54 | 9.8 | 4.1 | 9.0 | 66.1 | 72 | 42 | 39 | 6 | 30 | 66 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.59 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 13 | 13 | 5 | 2 | 3.84 | .290 | 1.20 | 8.0 | 2.9 | 5.4 | 86.2 | 76 | 37 | 37 | 7 | 28 | 52 | 2 | 0 | 0 | 1 | 7 | 2 | 2 | 3.90 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 13 | 13 | 4 | 4 | 4.65 | .314 | 1.36 | 9.6 | 2.7 | 3.9 | 79.1 | 84 | 44 | 41 | 9 | 24 | 34 | 1 | 0 | 0 | 1 | 6 | 1 | 2 | 4.57 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 13 | 13 | 5 | 6 | 5.38 | .321 | 1.39 | 8.9 | 3.6 | 4.0 | 72.0 | 71 | 44 | 43 | 8 | 29 | 32 | 1 | 0 | 0 | 0 | 7 | 2 | 0 | 4.85 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 12 | 12 | 4 | 5 | 4.69 | .308 | 1.32 | 8.5 | 3.4 | 5.6 | 71.0 | 67 | 49 | 37 | 10 | 27 | 44 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 4.77 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 34 | 0 | 2 | 2 | 2.98 | .271 | 1.12 | 6.2 | 3.9 | 9.8 | 48.1 | 33 | 18 | 16 | 6 | 21 | 52 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.77 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 35 | 0 | 1 | 4 | 4.14 | .291 | 1.21 | 9.2 | 1.8 | 6.8 | 41.1 | 42 | 19 | 19 | 6 | 8 | 31 | 0 | 5 | 2 | 0 | 0 | 1 | 0 | 4.05 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 26 | 0 | 1 | 1 | 4.50 | .314 | 1.28 | 7.9 | 3.7 | 10.1 | 32.0 | 28 | 19 | 16 | 4 | 13 | 36 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 3.88 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 23 | 0 | 2 | 4 | 7.04 | .328 | 1.47 | 8.7 | 4.8 | 9.3 | 30.2 | 29 | 25 | 24 | 5 | 16 | 31 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.70 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 45 | 18 | 0 | 2 | 0 | 4.43 | .337 | 1.52 | 9.5 | 4.5 | 7.2 | 20.1 | 21 | 12 | 10 | 1 | 10 | 16 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.55 |
| SP | Cuellar, M.Cuellar, Mike >> | 32 | 1969 | L | 44 | 10 | 0 | 1 | 1 | 4.88 | .308 | 1.30 | 9.7 | 2.3 | 5.3 | 27.2 | 29 | 15 | 15 | 4 | 7 | 16 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.63 |