| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 34 | 34 | 13 | 19 | 3.69 | .288 | 1.20 | 8.1 | 2.7 | 7.6 | 249.0 | 223 | 107 | 102 | 24 | 76 | 209 | 16 | 0 | 0 | 3 | 20 | 3 | 7 | 3.53 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 33 | 33 | 11 | 14 | 5.33 | .321 | 1.37 | 9.1 | 3.2 | 4.9 | 211.0 | 214 | 134 | 125 | 27 | 75 | 114 | 5 | 0 | 0 | 1 | 14 | 10 | 5 | 4.79 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 32 | 32 | 10 | 17 | 5.21 | .299 | 1.28 | 8.8 | 2.7 | 4.3 | 222.2 | 217 | 131 | 129 | 30 | 67 | 107 | 13 | 0 | 0 | 2 | 12 | 1 | 4 | 4.71 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 31 | 31 | 10 | 14 | 5.35 | .339 | 1.52 | 9.8 | 3.8 | 5.4 | 207.0 | 226 | 134 | 123 | 24 | 88 | 124 | 6 | 0 | 0 | 2 | 9 | 5 | 4 | 4.66 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 74 | 0 | 2 | 4 | 3.66 | .291 | 1.19 | 7.1 | 3.7 | 8.9 | 98.1 | 77 | 40 | 40 | 12 | 40 | 97 | 0 | 9 | 2 | 0 | 0 | 4 | 4 | 3.96 |
| RP | Pagan, E.Pagan, Emilio # >> | 28 | 2019 | R | 77 | 59 | 0 | 4 | 4 | 4.98 | .304 | 1.25 | 9.1 | 2.1 | 8.0 | 65.0 | 66 | 38 | 36 | 15 | 15 | 58 | 0 | 7 | 3 | 0 | 0 | 4 | 3 | 5.09 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 33 | 0 | 4 | 3 | 3.08 | .289 | 1.22 | 6.7 | 4.3 | 5.5 | 73.0 | 54 | 26 | 25 | 7 | 35 | 45 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 4.45 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 26 | 0 | 0 | 0 | 2.70 | .262 | 1.07 | 6.0 | 3.6 | 7.5 | 30.0 | 20 | 11 | 9 | 5 | 12 | 25 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4.70 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 11 | 2 | 2 | 2 | 4.68 | .319 | 1.41 | 10.7 | 2.3 | 3.4 | 32.2 | 38 | 17 | 17 | 4 | 8 | 12 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 4.63 |