| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 24 | 24 | 7 | 9 | 3.18 | .271 | 1.10 | 7.7 | 2.2 | 7.7 | 192.1 | 165 | 69 | 68 | 16 | 46 | 164 | 7 | 0 | 0 | 0 | 16 | 4 | 3 | 3.16 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 24 | 24 | 9 | 10 | 5.13 | .319 | 1.39 | 8.6 | 3.9 | 8.3 | 151.0 | 145 | 95 | 86 | 28 | 65 | 139 | 1 | 0 | 0 | 0 | 13 | 2 | 6 | 4.90 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 23 | 23 | 11 | 11 | 4.81 | .318 | 1.38 | 9.2 | 3.4 | 4.7 | 177.2 | 180 | 98 | 95 | 19 | 66 | 92 | 9 | 0 | 0 | 0 | 9 | 2 | 3 | 4.51 |
| SP | Coveleski, S.Coveleski, Stan # >> | 28 | 1917 | R | 62 | 21 | 21 | 6 | 10 | 5.09 | .333 | 1.46 | 9.1 | 4.1 | 3.4 | 141.1 | 143 | 80 | 80 | 22 | 64 | 54 | 1 | 0 | 0 | 1 | 9 | 5 | 3 | 5.73 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 60 | 0 | 5 | 3 | 3.03 | .266 | 1.03 | 6.8 | 2.6 | 8.2 | 77.1 | 58 | 29 | 26 | 5 | 22 | 70 | 0 | 6 | 4 | 0 | 0 | 4 | 3 | 3.04 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 59 | 4 | 0 | 1 | 0 | 0.00 | .316 | 1.38 | 6.8 | 6.8 | 6.8 | 4.1 | 3 | 0 | 0 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.75 |