| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 13 | 13 | 7 | 2 | 2.58 | .270 | 1.07 | 7.2 | 2.5 | 9.6 | 80.1 | 64 | 24 | 23 | 4 | 22 | 85 | 1 | 0 | 0 | 0 | 8 | 3 | 0 | 2.46 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 13 | 13 | 3 | 7 | 4.83 | .334 | 1.49 | 9.9 | 3.6 | 8.0 | 78.1 | 86 | 45 | 42 | 8 | 31 | 69 | 1 | 0 | 0 | 1 | 6 | 1 | 2 | 3.79 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 14 | 13 | 6 | 0 | 4.76 | .332 | 1.45 | 9.1 | 4.0 | 6.1 | 81.1 | 82 | 49 | 43 | 15 | 36 | 55 | 2 | 0 | 0 | 0 | 7 | 3 | 1 | 5.49 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 12 | 12 | 4 | 3 | 4.57 | .334 | 1.46 | 10.2 | 3.0 | 4.8 | 69.0 | 78 | 36 | 35 | 8 | 23 | 37 | 1 | 0 | 0 | 1 | 5 | 3 | 4 | 4.57 |
| CL | Gagne, E.Gagne, Eric $ >> | 27 | 2003 | R | 99 | 39 | 0 | 2 | 0 | 2.45 | .233 | 0.86 | 5.7 | 2.0 | 9.0 | 44.0 | 28 | 15 | 12 | 5 | 10 | 44 | 0 | 18 | 2 | 0 | 0 | 2 | 1 | 3.30 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 36 | 0 | 1 | 3 | 8.55 | .392 | 1.93 | 12.0 | 5.7 | 10.9 | 33.2 | 44 | 32 | 32 | 7 | 21 | 40 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 5.24 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 42 | 0 | 5 | 1 | 4.23 | .327 | 1.41 | 10.0 | 2.9 | 10.2 | 44.2 | 49 | 21 | 21 | 11 | 14 | 50 | 0 | 0 | 3 | 0 | 0 | 2 | 0 | 5.07 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 31 | 0 | 2 | 1 | 1.52 | .244 | 0.94 | 7.5 | 1.1 | 9.0 | 41.1 | 34 | 7 | 7 | 4 | 5 | 41 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 2.71 |