| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 33 | 33 | 14 | 8 | 3.61 | .288 | 1.20 | 9.0 | 1.7 | 8.5 | 206.2 | 207 | 88 | 83 | 27 | 40 | 194 | 2 | 0 | 0 | 0 | 21 | 4 | 3 | 3.46 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 31 | 11 | 8 | 5.11 | .309 | 1.33 | 8.9 | 3.1 | 8.6 | 171.0 | 169 | 100 | 97 | 29 | 59 | 164 | 2 | 0 | 0 | 1 | 11 | 1 | 3 | 4.34 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 30 | 30 | 10 | 9 | 5.09 | .341 | 1.54 | 10.5 | 3.4 | 6.2 | 184.0 | 215 | 114 | 104 | 17 | 69 | 127 | 0 | 0 | 0 | 0 | 15 | 2 | 4 | 3.98 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 69 | 0 | 7 | 9 | 4.92 | .307 | 1.31 | 9.3 | 2.5 | 9.6 | 64.0 | 66 | 42 | 35 | 9 | 18 | 68 | 0 | 34 | 6 | 0 | 0 | 1 | 0 | 3.59 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 71 | 0 | 3 | 3 | 3.23 | .293 | 1.23 | 6.9 | 4.2 | 8.5 | 78.0 | 60 | 31 | 28 | 6 | 36 | 74 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.53 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 84 | 0 | 6 | 3 | 3.04 | .283 | 1.17 | 7.1 | 3.5 | 8.5 | 94.2 | 74 | 38 | 32 | 11 | 37 | 89 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 3.84 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 47 | 0 | 4 | 2 | 3.62 | .322 | 1.43 | 6.7 | 6.3 | 10.0 | 54.2 | 40 | 23 | 22 | 7 | 38 | 60 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 4.57 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 38 | 0 | 1 | 0 | 4.22 | .319 | 1.38 | 7.5 | 5.1 | 6.2 | 42.2 | 35 | 22 | 20 | 4 | 24 | 29 | 0 | 0 | 1 | 0 | 0 | 1 | 7 | 4.64 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 51 | 0 | 6 | 0 | 5.75 | .333 | 1.49 | 8.2 | 5.3 | 6.2 | 76.2 | 69 | 50 | 49 | 12 | 45 | 52 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5.50 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 7 | 0 | 1 | 3 | 6.43 | .373 | 1.71 | 13.5 | 1.9 | 3.2 | 14.0 | 21 | 10 | 10 | 1 | 3 | 5 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.07 |