| SP | Arrieta, J.Arrieta, Jake † $ >> | 29 | 2015 | R | 93 | 33 | 33 | 17 | 8 | 3.93 | .304 | 1.30 | 8.3 | 3.4 | 7.2 | 229.0 | 210 | 106 | 100 | 18 | 87 | 184 | 3 | 0 | 0 | 1 | 21 | 3 | 5 | 3.59 |
| SP | Mathewson, C.Mathewson, Christy $$ >> | 28 | 1908 | R | 83 | 31 | 31 | 15 | 8 | 4.57 | .318 | 1.39 | 10.0 | 2.5 | 4.1 | 212.2 | 235 | 116 | 108 | 19 | 60 | 96 | 3 | 0 | 0 | 0 | 15 | 3 | 1 | 4.15 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 28 | 28 | 17 | 6 | 3.59 | .299 | 1.27 | 7.0 | 4.5 | 3.7 | 190.1 | 147 | 81 | 76 | 18 | 95 | 79 | 1 | 0 | 0 | 1 | 18 | 1 | 5 | 4.92 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 53 | 0 | 5 | 7 | 3.40 | .267 | 1.07 | 5.4 | 4.3 | 9.4 | 50.1 | 30 | 19 | 19 | 5 | 24 | 52 | 0 | 0 | 3 | 0 | 0 | 1 | 5 | 3.72 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 26 | 0 | 3 | 2 | 2.08 | .302 | 1.24 | 7.7 | 3.7 | 4.5 | 34.2 | 29 | 11 | 8 | 3 | 14 | 17 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 4.56 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 54 | 0 | 0 | 4 | 4.10 | .350 | 1.59 | 7.9 | 6.6 | 8.3 | 48.1 | 42 | 23 | 22 | 3 | 35 | 44 | 0 | 41 | 7 | 0 | 0 | 1 | 0 | 4.23 |