| SP | Sanchez, J.Sanchez, Jonathan >> | 27 | 2009 | L | 62 | 28 | 28 | 8 | 8 | 4.72 | .337 | 1.50 | 7.8 | 5.8 | 9.5 | 139.1 | 120 | 77 | 73 | 16 | 89 | 147 | 0 | 0 | 0 | 0 | 7 | 3 | 8 | 4.37 |
| SP | Harden, R.Harden, Rich # >> | 28 | 2009 | R | 67 | 27 | 27 | 7 | 7 | 5.61 | .347 | 1.58 | 10.0 | 4.3 | 9.3 | 131.2 | 145 | 82 | 82 | 24 | 63 | 136 | 0 | 0 | 0 | 0 | 7 | 2 | 10 | 4.79 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 28 | 2009 | R | 43 | 26 | 26 | 12 | 7 | 4.91 | .309 | 1.32 | 8.2 | 3.7 | 7.1 | 139.1 | 127 | 79 | 76 | 16 | 57 | 109 | 0 | 0 | 0 | 0 | 11 | 3 | 4 | 4.22 |
| SP | Kawakami, K.Kawakami, Kenshin # >> | 34 | 2009 | R | 39 | 26 | 26 | 7 | 6 | 6.54 | .384 | 1.83 | 12.6 | 4.0 | 5.6 | 115.2 | 161 | 85 | 84 | 20 | 51 | 72 | 0 | 0 | 0 | 0 | 0 | 4 | 11 | 5.44 |
| RP | Okajima, H.Okajima, Hideki >> | 34 | 2009 | L | 33 | 71 | 0 | 3 | 2 | 2.80 | .286 | 1.20 | 7.7 | 3.2 | 7.5 | 70.2 | 60 | 25 | 22 | 7 | 25 | 58 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.71 |
| SU | Gregerson, L.Gregerson, Luke # >> | 25 | 2009 | R | 50 | 44 | 0 | 1 | 4 | 4.57 | .309 | 1.32 | 7.3 | 4.6 | 10.5 | 43.1 | 35 | 23 | 22 | 6 | 22 | 50 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 4.09 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 29 | 2009 | R | 67 | 41 | 0 | 3 | 3 | 2.47 | .292 | 1.21 | 6.5 | 4.6 | 9.2 | 43.2 | 31 | 12 | 12 | 3 | 22 | 44 | 0 | 20 | 1 | 0 | 0 | 1 | 0 | 3.47 |
| RP | Howell, J.Howell, J.P. >> | 26 | 2009 | L | 62 | 57 | 0 | 8 | 2 | 4.06 | .301 | 1.29 | 8.3 | 3.4 | 9.0 | 51.0 | 47 | 25 | 23 | 8 | 19 | 51 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.16 |
| RP | Madson, R.Madson, Ryan >> | 29 | 2009 | R | 37 | 42 | 0 | 1 | 0 | 2.49 | .288 | 1.19 | 7.3 | 3.4 | 9.8 | 47.0 | 38 | 15 | 13 | 3 | 18 | 51 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2.87 |
| RP | Qualls, C.Qualls, Chad >> | 31 | 2009 | R | 41 | 34 | 0 | 5 | 1 | 3.35 | .322 | 1.41 | 10.1 | 2.6 | 5.8 | 48.1 | 54 | 18 | 18 | 3 | 14 | 31 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.46 |