| SP | Jurrjens, J.Jurrjens, Jair # >> | 23 | 2009 | R | 82 | 24 | 24 | 7 | 11 | 5.10 | .324 | 1.42 | 9.2 | 3.6 | 6.9 | 132.1 | 135 | 78 | 75 | 16 | 53 | 101 | 0 | 0 | 0 | 0 | 9 | 2 | 1 | 4.30 |
| SP | Dempster, R.Dempster, Ryan # >> | 32 | 2009 | R | 57 | 23 | 23 | 9 | 7 | 4.60 | .308 | 1.30 | 8.9 | 2.8 | 7.2 | 135.0 | 134 | 71 | 69 | 12 | 42 | 108 | 1 | 0 | 0 | 1 | 12 | 4 | 2 | 3.58 |
| SP | Scherzer, M.Scherzer, Max >> | 25 | 2009 | R | 50 | 23 | 22 | 4 | 11 | 8.59 | .402 | 1.99 | 14.0 | 4.0 | 9.0 | 95.1 | 148 | 96 | 91 | 15 | 42 | 95 | 0 | 0 | 0 | 0 | 6 | 2 | 3 | 4.44 |
| SP | Buehrle, M.Buehrle, Mark >> | 30 | 2009 | L | 47 | 23 | 22 | 5 | 9 | 5.82 | .341 | 1.55 | 11.4 | 2.6 | 5.8 | 123.2 | 156 | 86 | 80 | 21 | 36 | 79 | 1 | 0 | 0 | 0 | 9 | 0 | 5 | 4.81 |
| SP | Johnson, R.Johnson, Randy >> | 46 | 2009 | L | 45 | 25 | 22 | 3 | 10 | 6.61 | .358 | 1.64 | 11.0 | 3.7 | 6.6 | 94.0 | 115 | 71 | 69 | 21 | 39 | 69 | 0 | 0 | 0 | 0 | 1 | 3 | 3 | 5.78 |
| RP | Mijares, J.Mijares, Jose † >> | 25 | 2009 | L | 51 | 71 | 0 | 5 | 1 | 1.84 | .287 | 1.19 | 6.8 | 3.9 | 5.5 | 83.0 | 63 | 22 | 17 | 6 | 36 | 51 | 0 | 7 | 0 | 0 | 0 | 1 | 0 | 4.05 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 97 | 90 | 0 | 6 | 5 | 4.48 | .329 | 1.44 | 9.1 | 3.9 | 11.0 | 90.1 | 91 | 48 | 45 | 13 | 39 | 110 | 0 | 2 | 2 | 0 | 0 | 3 | 5 | 3.83 |
| RP | Miller, T.Miller, Trever >> | 36 | 2009 | L | 90 | 84 | 0 | 5 | 1 | 3.78 | .286 | 1.15 | 7.8 | 2.6 | 8.4 | 102.1 | 88 | 47 | 43 | 13 | 30 | 95 | 0 | 3 | 1 | 0 | 0 | 5 | 1 | 3.82 |
| RP | Affeldt, J.Affeldt, Jeremy >> | 30 | 2009 | L | 66 | 72 | 0 | 4 | 1 | 3.26 | .314 | 1.36 | 7.7 | 4.5 | 7.1 | 91.0 | 78 | 40 | 33 | 9 | 46 | 72 | 0 | 10 | 2 | 0 | 0 | 1 | 3 | 4.25 |
| RP | Byrdak, T.Byrdak, Tim † >> | 36 | 2009 | L | 63 | 56 | 0 | 7 | 2 | 3.70 | .322 | 1.42 | 8.0 | 4.8 | 8.9 | 73.0 | 65 | 32 | 30 | 7 | 39 | 72 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 3.88 |