| SP | Johnson, R.Johnson, Randy $ >> | 41 | 2004 | L | 90 | 10 | 10 | 3 | 2 | 3.84 | .304 | 1.29 | 8.5 | 3.2 | 9.3 | 70.1 | 66 | 35 | 30 | 8 | 25 | 72 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.54 |
| SP | Buehler, W.Buehler, Walker $ >> | 23 | 2018 | R | 85 | 10 | 10 | 4 | 4 | 4.96 | .320 | 1.41 | 9.0 | 3.8 | 8.9 | 61.2 | 61 | 35 | 34 | 6 | 26 | 60 | 0 | 0 | 0 | 0 | 2 | 0 | 3 | 3.59 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 83 | 9 | 9 | 6 | 3 | 3.98 | .318 | 1.33 | 8.5 | 3.5 | 8.0 | 54.1 | 51 | 24 | 24 | 7 | 21 | 48 | 0 | 0 | 0 | 0 | 6 | 4 | 0 | 4.30 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 65 | 11 | 9 | 1 | 4 | 5.73 | .327 | 1.45 | 9.0 | 4.1 | 6.9 | 55.0 | 55 | 38 | 35 | 12 | 25 | 42 | 0 | 1 | 0 | 0 | 4 | 0 | 2 | 5.67 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 19 | 0 | 2 | 1 | 3.52 | .337 | 1.48 | 9.4 | 3.9 | 8.6 | 23.0 | 24 | 9 | 9 | 0 | 10 | 22 | 0 | 8 | 2 | 0 | 0 | 1 | 0 | 2.52 |
| SU | Devine, J.Devine, Joey >> | 25 | 2008 | R | 78 | 18 | 0 | 2 | 3 | 7.90 | .431 | 2.27 | 17.3 | 4.2 | 9.0 | 13.2 | 25 | 15 | 12 | 4 | 6 | 13 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 6.38 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 74 | 25 | 0 | 0 | 3 | 4.68 | .285 | 1.19 | 7.0 | 3.9 | 9.3 | 32.2 | 25 | 17 | 17 | 8 | 14 | 33 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.50 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 71 | 22 | 0 | 0 | 1 | 2.73 | .248 | 0.95 | 6.2 | 2.4 | 9.7 | 26.1 | 18 | 8 | 8 | 5 | 7 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.27 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 72 | 19 | 0 | 0 | 1 | 4.37 | .376 | 1.76 | 8.6 | 7.8 | 7.4 | 22.2 | 21 | 11 | 11 | 2 | 19 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.27 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 66 | 8 | 0 | 0 | 1 | 6.67 | .377 | 1.78 | 12.0 | 4.0 | 8.0 | 27.0 | 36 | 20 | 20 | 5 | 12 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.07 |