| SP | Johnson, W.Johnson, Walter # $ >> | 26 | 1913 | R | 95 | 31 | 31 | 14 | 13 | 3.13 | .263 | 1.07 | 7.7 | 1.9 | 4.7 | 218.2 | 187 | 92 | 76 | 16 | 46 | 113 | 9 | 0 | 0 | 3 | 20 | 1 | 4 | 3.56 |
| SP | Kluber, C.Kluber, Corey # $ >> | 31 | 2017 | R | 90 | 30 | 30 | 10 | 11 | 5.13 | .323 | 1.41 | 9.9 | 2.9 | 8.8 | 194.2 | 213 | 112 | 111 | 30 | 62 | 190 | 0 | 0 | 0 | 0 | 12 | 4 | 5 | 4.07 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 29 | 29 | 10 | 10 | 4.67 | .307 | 1.32 | 8.1 | 3.8 | 5.1 | 198.1 | 179 | 109 | 103 | 29 | 83 | 113 | 4 | 0 | 0 | 2 | 13 | 2 | 4 | 5.05 |
| CL | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 95 | 56 | 0 | 4 | 8 | 1.91 | .292 | 1.20 | 6.6 | 4.3 | 9.2 | 56.2 | 41 | 13 | 12 | 3 | 27 | 57 | 0 | 36 | 3 | 0 | 0 | 2 | 1 | 3.21 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 70 | 0 | 5 | 2 | 4.42 | .348 | 1.59 | 9.8 | 4.6 | 8.3 | 77.1 | 84 | 46 | 38 | 11 | 39 | 71 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.57 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 36 | 0 | 4 | 1 | 1.52 | .248 | 0.97 | 5.5 | 3.3 | 9.0 | 41.1 | 25 | 9 | 7 | 2 | 15 | 41 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 2.80 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 17 | 0 | 2 | 3 | 4.60 | .373 | 1.72 | 9.0 | 7.2 | 7.8 | 15.2 | 15 | 8 | 8 | 2 | 12 | 13 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 5.60 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 6 | 0 | 0 | 0 | 1.08 | .167 | 0.60 | 4.5 | 1.1 | 11.3 | 8.1 | 4 | 1 | 1 | 1 | 1 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.50 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 7 | 0 | 0 | 1 | 4.05 | .394 | 1.95 | 13.5 | 6.0 | 3.0 | 6.2 | 9 | 3 | 3 | 3 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 10.83 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 12 | 0 | 0 | 0 | 4.73 | .333 | 1.50 | 6.9 | 6.9 | 11.8 | 13.1 | 10 | 7 | 7 | 2 | 10 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.69 |