| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 19 | 19 | 6 | 8 | 4.05 | .319 | 1.39 | 8.5 | 4.1 | 9.7 | 122.1 | 115 | 57 | 55 | 19 | 55 | 132 | 1 | 0 | 0 | 1 | 10 | 2 | 3 | 4.26 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 18 | 18 | 5 | 11 | 6.21 | .353 | 1.61 | 11.2 | 3.4 | 7.5 | 108.2 | 134 | 80 | 75 | 20 | 41 | 90 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 4.96 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 17 | 17 | 7 | 9 | 4.12 | .299 | 1.28 | 8.4 | 3.1 | 4.9 | 135.1 | 126 | 69 | 62 | 18 | 47 | 73 | 9 | 0 | 0 | 1 | 7 | 0 | 2 | 4.70 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 17 | 17 | 4 | 8 | 6.28 | .354 | 1.61 | 10.7 | 3.9 | 5.0 | 104.2 | 124 | 76 | 73 | 10 | 45 | 58 | 1 | 0 | 0 | 0 | 7 | 3 | 1 | 4.52 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 17 | 17 | 8 | 6 | 4.19 | .300 | 1.27 | 8.1 | 3.4 | 6.9 | 118.0 | 106 | 63 | 55 | 10 | 44 | 91 | 5 | 0 | 0 | 1 | 9 | 2 | 3 | 3.73 |
| RP | Hader, J.Hader, Josh # >> | 24 | 2018 | L | 93 | 44 | 0 | 5 | 1 | 5.20 | .309 | 1.34 | 8.6 | 3.5 | 11.5 | 64.0 | 61 | 37 | 37 | 9 | 25 | 82 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.44 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 31 | 0 | 1 | 4 | 9.10 | .399 | 1.99 | 9.9 | 8.4 | 8.7 | 29.2 | 32 | 31 | 30 | 5 | 27 | 28 | 0 | 4 | 3 | 0 | 0 | 0 | 2 | 6.10 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 27 | 0 | 1 | 3 | 5.58 | .366 | 1.71 | 8.1 | 7.4 | 6.3 | 40.1 | 36 | 28 | 25 | 7 | 33 | 28 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 6.43 |
| RP | Garber, G.Garber, Gene >> | 31 | 1978 | R | 40 | 17 | 0 | 1 | 0 | 5.27 | .311 | 1.35 | 7.7 | 4.7 | 7.3 | 27.1 | 23 | 17 | 16 | 4 | 14 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.85 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 1 | 1 | 1 | 0 | 3.52 | .324 | 1.43 | 11.6 | 2.6 | 7.7 | 7.2 | 9 | 3 | 3 | 1 | 2 | 6 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.00 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 3 | 0 | 0 | 0 | 8.10 | .444 | 2.40 | 15.0 | 9.0 | 6.0 | 3.1 | 5 | 3 | 3 | 2 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 13.33 |