| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 21 | 21 | 7 | 7 | 5.20 | .317 | 1.37 | 10.2 | 2.1 | 5.8 | 109.0 | 124 | 71 | 63 | 13 | 25 | 70 | 0 | 0 | 0 | 0 | 11 | 3 | 1 | 4.04 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 22 | 22 | 9 | 6 | 4.04 | .318 | 1.39 | 8.9 | 3.7 | 8.5 | 131.1 | 129 | 62 | 59 | 16 | 54 | 124 | 0 | 0 | 0 | 0 | 13 | 1 | 1 | 3.95 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 22 | 21 | 9 | 8 | 4.93 | .318 | 1.36 | 9.3 | 3.0 | 5.1 | 122.1 | 126 | 71 | 67 | 20 | 40 | 69 | 1 | 0 | 0 | 0 | 11 | 5 | 2 | 5.11 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 62 | 0 | 2 | 2 | 5.13 | .327 | 1.43 | 7.9 | 5.0 | 9.5 | 72.0 | 63 | 43 | 41 | 15 | 40 | 76 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 5.35 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 52 | 0 | 5 | 2 | 4.15 | .305 | 1.27 | 8.7 | 2.9 | 8.9 | 60.2 | 58 | 29 | 28 | 7 | 19 | 59 | 0 | 0 | 3 | 0 | 0 | 3 | 1 | 3.65 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 46 | 0 | 5 | 2 | 4.83 | .298 | 1.27 | 8.6 | 2.9 | 10.1 | 50.1 | 48 | 27 | 27 | 9 | 16 | 56 | 0 | 0 | 2 | 0 | 0 | 0 | 4 | 4.06 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 38 | 0 | 2 | 2 | 4.78 | .294 | 1.25 | 7.6 | 3.7 | 8.8 | 58.1 | 49 | 31 | 31 | 9 | 24 | 57 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4.29 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 51 | 0 | 2 | 3 | 5.31 | .285 | 1.20 | 8.5 | 2.4 | 7.9 | 57.2 | 54 | 37 | 34 | 10 | 15 | 50 | 0 | 3 | 8 | 0 | 0 | 0 | 4 | 4.32 |
| CL | Wagner, B.Wagner, Billy $ >> | 28 | 1999 | L | 95 | 55 | 0 | 3 | 9 | 4.01 | .349 | 1.58 | 7.9 | 6.4 | 9.3 | 58.1 | 51 | 31 | 26 | 11 | 41 | 60 | 0 | 24 | 5 | 0 | 0 | 2 | 1 | 5.62 |