| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 18 | 18 | 9 | 5 | 2.64 | .266 | 1.07 | 6.9 | 2.7 | 5.7 | 126.0 | 97 | 42 | 37 | 11 | 38 | 80 | 1 | 0 | 0 | 0 | 14 | 2 | 1 | 3.82 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 18 | 18 | 5 | 8 | 5.60 | .342 | 1.53 | 10.1 | 3.7 | 7.4 | 101.1 | 113 | 75 | 63 | 17 | 42 | 83 | 2 | 0 | 0 | 0 | 5 | 3 | 3 | 4.88 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 18 | 17 | 10 | 5 | 4.19 | .329 | 1.46 | 9.7 | 3.6 | 5.6 | 109.2 | 117 | 52 | 51 | 11 | 43 | 68 | 1 | 0 | 0 | 1 | 9 | 1 | 2 | 4.28 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 53 | 0 | 3 | 1 | 2.44 | .244 | 0.95 | 6.1 | 2.5 | 10.8 | 44.1 | 30 | 15 | 12 | 3 | 12 | 53 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 2.36 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 19 | 0 | 1 | 1 | 3.86 | .311 | 1.36 | 7.1 | 5.1 | 9.6 | 14.0 | 11 | 6 | 6 | 1 | 8 | 15 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 3.50 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 45 | 0 | 2 | 2 | 2.93 | .276 | 1.14 | 6.3 | 4.2 | 6.9 | 30.2 | 21 | 11 | 10 | 0 | 14 | 23 | 0 | 6 | 1 | 0 | 0 | 0 | 3 | 2.87 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 18 | 0 | 2 | 1 | 1.53 | .312 | 1.30 | 7.9 | 4.2 | 5.8 | 17.2 | 15 | 3 | 3 | 1 | 8 | 11 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.06 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 17 | 0 | 0 | 0 | 9.98 | .418 | 2.09 | 12.6 | 6.6 | 7.8 | 15.1 | 21 | 17 | 17 | 2 | 11 | 13 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 5.40 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 12 | 0 | 2 | 1 | 3.81 | .345 | 1.56 | 9.2 | 4.8 | 3.8 | 52.0 | 53 | 26 | 22 | 3 | 28 | 22 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.58 |