| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 97 | 31 | 31 | 14 | 13 | 3.86 | .271 | 1.09 | 7.5 | 2.2 | 7.8 | 242.1 | 203 | 104 | 104 | 30 | 60 | 211 | 15 | 0 | 0 | 2 | 18 | 7 | 3 | 3.70 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 68 | 30 | 30 | 7 | 15 | 5.93 | .357 | 1.66 | 11.8 | 3.2 | 4.8 | 195.2 | 256 | 130 | 129 | 23 | 69 | 104 | 1 | 0 | 0 | 0 | 9 | 1 | 6 | 4.54 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 66 | 30 | 30 | 16 | 11 | 4.17 | .305 | 1.30 | 8.9 | 2.8 | 4.3 | 235.0 | 233 | 118 | 109 | 28 | 72 | 111 | 11 | 0 | 0 | 0 | 15 | 5 | 6 | 4.59 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 29 | 29 | 14 | 8 | 4.40 | .322 | 1.40 | 9.0 | 3.6 | 5.2 | 186.1 | 187 | 100 | 91 | 21 | 74 | 107 | 0 | 0 | 0 | 0 | 16 | 4 | 2 | 4.58 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 74 | 0 | 4 | 5 | 3.86 | .284 | 1.18 | 7.6 | 3.1 | 7.5 | 95.2 | 80 | 41 | 41 | 15 | 33 | 79 | 0 | 7 | 6 | 0 | 0 | 1 | 1 | 4.46 |
| RP | Zimmerman, J.Zimmerman, Jeff † >> | 27 | 1999 | R | 70 | 65 | 0 | 6 | 4 | 2.84 | .252 | 0.98 | 5.9 | 3.0 | 5.7 | 82.1 | 54 | 27 | 26 | 9 | 27 | 52 | 0 | 15 | 3 | 0 | 0 | 2 | 0 | 4.22 |
| RP | Rhodes, A.Rhodes, Arthur # >> | 32 | 2001 | L | 65 | 42 | 0 | 0 | 4 | 4.05 | .310 | 1.35 | 8.6 | 3.7 | 8.4 | 46.2 | 44 | 22 | 21 | 6 | 19 | 43 | 0 | 8 | 0 | 0 | 0 | 0 | 4 | 4.07 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 57 | 25 | 0 | 4 | 2 | 2.20 | .232 | 0.87 | 4.8 | 3.2 | 9.3 | 28.2 | 15 | 7 | 7 | 1 | 10 | 29 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 2.57 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 27 | 0 | 0 | 1 | 6.32 | .329 | 1.40 | 10.5 | 2.3 | 4.6 | 31.1 | 36 | 22 | 22 | 4 | 8 | 16 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.61 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 8 | 0 | 1 | 0 | 2.51 | .295 | 1.26 | 10.3 | 1.3 | 5.8 | 14.1 | 16 | 4 | 4 | 3 | 2 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.93 |