| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 99 | 32 | 32 | 13 | 13 | 3.47 | .269 | 1.08 | 7.7 | 2.0 | 8.6 | 220.2 | 189 | 89 | 85 | 20 | 49 | 211 | 6 | 0 | 0 | 2 | 20 | 6 | 3 | 3.01 |
| SP | Alexander, P.Alexander, Pete † # >> | 28 | 1915 | R | 88 | 31 | 31 | 21 | 10 | 3.17 | .257 | 1.02 | 7.0 | 2.2 | 4.6 | 241.0 | 187 | 88 | 85 | 17 | 60 | 123 | 17 | 0 | 0 | 6 | 20 | 3 | 3 | 3.68 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 83 | 29 | 29 | 11 | 9 | 4.80 | .309 | 1.33 | 9.6 | 2.3 | 7.6 | 193.0 | 206 | 106 | 103 | 31 | 50 | 162 | 5 | 0 | 0 | 1 | 14 | 3 | 2 | 4.23 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 53 | 0 | 6 | 4 | 5.18 | .315 | 1.36 | 9.4 | 2.9 | 8.2 | 66.0 | 69 | 38 | 38 | 10 | 21 | 60 | 0 | 7 | 4 | 0 | 0 | 1 | 0 | 4.15 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 40 | 0 | 3 | 3 | 4.31 | .262 | 1.04 | 7.5 | 1.9 | 8.3 | 48.0 | 40 | 23 | 23 | 7 | 10 | 44 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.75 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 29 | 0 | 2 | 0 | 4.68 | .295 | 1.22 | 8.2 | 3.1 | 5.9 | 32.2 | 29 | 17 | 17 | 4 | 11 | 21 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 4.44 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 25 | 0 | 0 | 1 | 4.72 | .304 | 1.25 | 9.0 | 2.4 | 7.1 | 34.1 | 34 | 18 | 18 | 5 | 9 | 27 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 4.29 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 52 | 10 | 2 | 2 | 1 | 3.38 | .314 | 1.38 | 8.6 | 3.8 | 5.3 | 24.0 | 23 | 11 | 9 | 1 | 10 | 14 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 3.63 |