| SP | Tiant, L.Tiant, Luis # >> | 28 | 1968 | R | 97 | 31 | 31 | 12 | 12 | 4.30 | .289 | 1.19 | 7.5 | 3.3 | 8.4 | 219.2 | 182 | 112 | 105 | 20 | 80 | 204 | 4 | 0 | 0 | 2 | 16 | 6 | 1 | 3.50 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 30 | 30 | 7 | 13 | 6.16 | .352 | 1.61 | 10.0 | 4.5 | 7.8 | 174.0 | 193 | 123 | 119 | 26 | 87 | 151 | 0 | 0 | 0 | 0 | 11 | 3 | 3 | 4.76 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 30 | 30 | 11 | 17 | 5.45 | .333 | 1.49 | 10.0 | 3.4 | 4.6 | 204.2 | 227 | 130 | 124 | 23 | 77 | 105 | 9 | 0 | 0 | 0 | 10 | 3 | 6 | 4.61 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 63 | 27 | 27 | 10 | 10 | 4.95 | .339 | 1.52 | 10.2 | 3.5 | 4.6 | 156.1 | 177 | 94 | 86 | 16 | 61 | 80 | 0 | 0 | 0 | 0 | 12 | 3 | 1 | 4.54 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 79 | 0 | 7 | 5 | 4.46 | .311 | 1.30 | 7.7 | 4.0 | 7.8 | 119.0 | 102 | 63 | 59 | 13 | 53 | 103 | 0 | 9 | 4 | 0 | 0 | 6 | 0 | 4.18 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 65 | 0 | 2 | 2 | 6.21 | .354 | 1.60 | 10.8 | 3.7 | 8.6 | 82.2 | 98 | 63 | 57 | 15 | 34 | 78 | 0 | 9 | 2 | 0 | 0 | 4 | 0 | 4.87 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 58 | 0 | 1 | 4 | 6.94 | .358 | 1.64 | 9.9 | 5.0 | 10.4 | 59.2 | 65 | 47 | 46 | 10 | 33 | 68 | 0 | 5 | 3 | 0 | 0 | 2 | 0 | 4.68 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 3 | 1 | 1 | 1 | 8.74 | .443 | 2.38 | 15.5 | 6.5 | 11.5 | 11.1 | 19 | 11 | 11 | 1 | 8 | 14 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 3.82 |
| SP | McQuillan, G.McQuillan, George >> | 23 | 1908 | R | 48 | 22 | 0 | 2 | 2 | 3.79 | .313 | 1.36 | 7.9 | 4.5 | 4.3 | 40.1 | 35 | 17 | 17 | 2 | 20 | 19 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4.20 |