| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 7 | 7 | 2 | 2 | 4.05 | .302 | 1.30 | 7.7 | 4.1 | 11.0 | 40.0 | 34 | 18 | 18 | 7 | 18 | 49 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 4.18 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 7 | 7 | 2 | 2 | 5.71 | .309 | 1.32 | 9.2 | 2.6 | 9.2 | 41.0 | 42 | 27 | 26 | 4 | 12 | 42 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3.17 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 7 | 7 | 0 | 5 | 12.31 | .452 | 2.38 | 18.8 | 3.3 | 4.9 | 22.2 | 46 | 33 | 31 | 10 | 8 | 12 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 9.18 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 8 | 6 | 2 | 2 | 5.19 | .347 | 1.55 | 10.0 | 4.0 | 6.1 | 43.1 | 48 | 28 | 25 | 6 | 19 | 29 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 4.93 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 17 | 0 | 1 | 1 | 6.65 | .361 | 1.70 | 14.1 | 1.2 | 5.9 | 23.0 | 36 | 18 | 17 | 4 | 3 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.35 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 15 | 0 | 0 | 0 | 6.38 | .375 | 1.80 | 8.5 | 8.0 | 12.0 | 18.1 | 17 | 13 | 13 | 1 | 16 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.72 |
| CL | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 20 | 0 | 0 | 3 | 4.70 | .343 | 1.52 | 7.8 | 5.9 | 5.5 | 23.0 | 20 | 12 | 12 | 3 | 15 | 14 | 0 | 4 | 3 | 0 | 0 | 1 | 3 | 5.57 |