| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 40 | 40 | 15 | 14 | 4.38 | .310 | 1.32 | 9.3 | 2.5 | 5.2 | 255.0 | 264 | 130 | 124 | 26 | 72 | 147 | 1 | 0 | 0 | 0 | 23 | 8 | 4 | 4.11 |
| SP | Richard, J.Richard, J.R. # >> | 30 | 1980 | R | 90 | 38 | 38 | 16 | 10 | 3.04 | .283 | 1.17 | 7.3 | 3.3 | 7.9 | 252.0 | 203 | 97 | 85 | 20 | 93 | 220 | 4 | 0 | 0 | 2 | 27 | 3 | 3 | 3.43 |
| SP | Johnson, R.Johnson, Randy # $ >> | 41 | 2004 | L | 84 | 37 | 37 | 12 | 16 | 5.03 | .328 | 1.46 | 9.7 | 3.4 | 8.1 | 218.1 | 236 | 133 | 122 | 34 | 83 | 197 | 3 | 0 | 0 | 0 | 16 | 1 | 2 | 4.38 |
| SP | Fernandez, J.Fernandez, Jose $ >> | 21 | 2013 | R | 76 | 36 | 36 | 17 | 13 | 3.82 | .304 | 1.29 | 8.0 | 3.6 | 7.1 | 226.1 | 201 | 116 | 96 | 22 | 90 | 178 | 0 | 0 | 0 | 0 | 23 | 5 | 4 | 3.95 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 31 | 31 | 12 | 9 | 4.52 | .328 | 1.43 | 7.5 | 5.3 | 3.6 | 197.1 | 165 | 107 | 99 | 22 | 117 | 79 | 1 | 0 | 0 | 1 | 16 | 7 | 2 | 5.54 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 73 | 0 | 7 | 7 | 4.00 | .313 | 1.35 | 8.3 | 3.9 | 8.6 | 69.2 | 64 | 31 | 31 | 7 | 30 | 66 | 0 | 42 | 5 | 0 | 0 | 1 | 2 | 3.75 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 95 | 0 | 5 | 4 | 2.63 | .305 | 1.30 | 7.3 | 4.4 | 7.9 | 89.0 | 72 | 27 | 26 | 9 | 44 | 78 | 0 | 4 | 5 | 0 | 0 | 1 | 0 | 4.08 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 101 | 0 | 4 | 1 | 1.73 | .234 | 0.92 | 5.3 | 3.0 | 7.0 | 73.0 | 43 | 15 | 14 | 2 | 24 | 57 | 0 | 1 | 4 | 0 | 0 | 0 | 5 | 2.78 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 76 | 40 | 0 | 3 | 2 | 4.07 | .284 | 1.17 | 6.0 | 4.5 | 6.9 | 42.0 | 28 | 20 | 19 | 2 | 21 | 32 | 0 | 3 | 2 | 0 | 0 | 1 | 4 | 3.67 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 20 | 0 | 0 | 1 | 3.29 | .328 | 1.46 | 6.9 | 6.9 | 9.7 | 13.2 | 10 | 6 | 5 | 2 | 10 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.15 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 8 | 0 | 2 | 0 | 1.13 | .368 | 1.75 | 6.8 | 9.0 | 4.5 | 8.0 | 6 | 2 | 1 | 1 | 8 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.63 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 24 | 0 | 0 | 0 | 1.82 | .265 | 1.08 | 6.0 | 3.9 | 6.7 | 39.2 | 26 | 9 | 8 | 2 | 17 | 29 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.49 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 29 | 0 | 2 | 1 | 4.54 | .312 | 1.32 | 8.9 | 3.0 | 5.8 | 105.0 | 104 | 57 | 53 | 11 | 35 | 68 | 0 | 0 | 0 | 0 | 0 | 4 | 5 | 4.18 |