| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 27 | 27 | 10 | 11 | 4.32 | .321 | 1.39 | 8.1 | 4.5 | 8.0 | 175.0 | 157 | 90 | 84 | 19 | 87 | 156 | 1 | 0 | 0 | 0 | 12 | 4 | 1 | 4.19 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 26 | 26 | 8 | 9 | 6.31 | .361 | 1.67 | 11.7 | 3.4 | 8.9 | 132.2 | 172 | 98 | 93 | 21 | 50 | 131 | 0 | 0 | 0 | 0 | 11 | 3 | 11 | 4.29 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 25 | 25 | 8 | 10 | 5.18 | .331 | 1.47 | 10.3 | 3.0 | 3.9 | 170.1 | 194 | 106 | 98 | 18 | 57 | 74 | 2 | 0 | 0 | 0 | 11 | 2 | 2 | 4.55 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 25 | 25 | 11 | 7 | 3.98 | .302 | 1.29 | 9.0 | 2.6 | 4.0 | 181.0 | 181 | 91 | 80 | 22 | 53 | 80 | 12 | 0 | 0 | 0 | 13 | 1 | 5 | 4.59 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 23 | 23 | 10 | 7 | 3.69 | .299 | 1.26 | 7.3 | 4.1 | 4.6 | 146.1 | 119 | 65 | 60 | 21 | 66 | 75 | 1 | 0 | 0 | 0 | 13 | 2 | 4 | 5.24 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 63 | 0 | 1 | 1 | 2.36 | .267 | 1.07 | 6.0 | 3.7 | 9.1 | 91.2 | 61 | 27 | 24 | 6 | 37 | 92 | 0 | 9 | 1 | 0 | 0 | 2 | 4 | 3.12 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 61 | 0 | 5 | 3 | 4.21 | .312 | 1.35 | 7.9 | 4.2 | 8.5 | 68.1 | 60 | 36 | 32 | 5 | 32 | 64 | 0 | 4 | 6 | 0 | 0 | 1 | 5 | 3.53 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 51 | 0 | 5 | 5 | 3.95 | .313 | 1.37 | 8.5 | 3.8 | 7.9 | 57.0 | 54 | 28 | 25 | 9 | 24 | 50 | 0 | 6 | 5 | 0 | 0 | 0 | 1 | 4.56 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 53 | 41 | 0 | 4 | 5 | 4.48 | .328 | 1.45 | 8.3 | 4.8 | 9.1 | 64.1 | 59 | 32 | 32 | 8 | 34 | 65 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.23 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 1 | 1 | 0 | 0 | 10.38 | .350 | 1.38 | 13.5 | 0.0 | 6.8 | 4.1 | 6 | 5 | 5 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.50 |
| SP | Russell, R.Russell, Reb >> | 27 | 1916 | L | 52 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | 0.0 | 0.0 | 0.0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| SP | Sparks, T.Sparks, Tully >> | 32 | 1906 | R | 46 | 25 | 0 | 3 | 4 | 5.11 | .330 | 1.48 | 9.6 | 3.7 | 2.3 | 44.0 | 47 | 25 | 25 | 4 | 18 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 4.91 |