| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 31 | 31 | 8 | 17 | 6.03 | .341 | 1.48 | 10.3 | 3.0 | 9.1 | 194.0 | 223 | 139 | 130 | 46 | 64 | 196 | 1 | 0 | 0 | 0 | 11 | 14 | 8 | 5.27 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 85 | 31 | 30 | 8 | 10 | 4.88 | .320 | 1.40 | 9.6 | 3.1 | 4.3 | 167.2 | 178 | 104 | 91 | 26 | 57 | 80 | 0 | 0 | 0 | 0 | 9 | 2 | 3 | 5.13 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 30 | 30 | 12 | 13 | 5.25 | .356 | 1.63 | 11.0 | 3.7 | 5.3 | 209.0 | 255 | 139 | 122 | 31 | 86 | 123 | 2 | 0 | 0 | 0 | 14 | 6 | 3 | 5.07 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 63 | 0 | 0 | 6 | 4.86 | .323 | 1.41 | 10.1 | 2.6 | 8.0 | 63.0 | 71 | 39 | 34 | 8 | 18 | 56 | 0 | 36 | 6 | 0 | 0 | 1 | 1 | 3.78 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 82 | 0 | 9 | 7 | 3.81 | .319 | 1.35 | 7.1 | 5.0 | 9.6 | 104.0 | 82 | 58 | 44 | 12 | 58 | 111 | 0 | 1 | 5 | 0 | 0 | 6 | 0 | 4.21 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 74 | 0 | 4 | 5 | 5.61 | .341 | 1.54 | 10.4 | 3.6 | 9.8 | 78.2 | 90 | 54 | 49 | 20 | 31 | 85 | 0 | 2 | 2 | 0 | 0 | 1 | 5 | 5.38 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 62 | 0 | 0 | 0 | 4.50 | .307 | 1.31 | 7.7 | 4.1 | 9.8 | 70.0 | 60 | 40 | 35 | 12 | 32 | 76 | 0 | 2 | 4 | 0 | 0 | 1 | 0 | 4.47 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 45 | 0 | 2 | 3 | 4.74 | .312 | 1.36 | 8.3 | 4.0 | 8.3 | 49.1 | 45 | 31 | 26 | 8 | 22 | 45 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.63 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 34 | 0 | 1 | 1 | 4.43 | .280 | 1.16 | 8.4 | 2.3 | 7.0 | 44.2 | 41 | 26 | 22 | 9 | 11 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.86 |